Abbott Laboratories Corporation

Medimmune Limited

Bruce J Dille

Larry G Birkenmeyer

Suresh M Desai

George J Dawson

Anthony Scott Muerhoff

Ruthie E Coffey

Partha S Chowdhury

John J Carrino

Meina Liang

Susan E Brophy

Jon D Kratochvil

Ronald L Marshall

Reena Varkey

Natalie A Solomon

Koustubh Ranade

Yen-Wah Lee

Yihong Yao

Katie Streicher

Thomas G Laffler

Lydia Greenlees

Ethan Grant

Hsiang-Yun Y Hu

Gerard Davis

Melissa Parker

Laurie A Rinehardt

Nicolette Jeanblanc

This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

Methods of using antibodies to determine periostin levels in a sample

The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of, and methods of using these polynucleotides and polypeptides in the detection ofantibodies or anti-antibodies in a subject. The invention finds particular useful application in identifying recent exposure to

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The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of thespeciesand. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.

The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of thespeciesandSuch genes and proteins have many beneficial diagnostic as well as therapeutic uses.

An improved, 'gap filling' embodiment of the Ligase Chain Reaction (LCR) is described. Gap filling LCR is LCR wherein at least one of the probes is recessed so that a gap is formed between the adjacent probes when they are hybridized to target. The gap is filled using polymerase and deoxyribonucleotide triphosphates before ligation of the probes together. There are single and double gap versions, depending on whether one or two probes are recessed and require filling before ligation. The improvement resides in selecting and using target sequences such that only a single type, or two types, of deoxyribonucleotide triphosphate(s) are required to fill double gaps each being 1-10 bases in length, preferably 1-3 bases. Probes having specific sequences are claimed for a number of pathogens.

Amplification of target nucleic acids using gap filling ligase chain

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Antioch, IL, United States of America

Bruce J Dille