Becton Dickinson and Company Limited

Bruce Haywood

Bradley M Wilkinson

Jamieson William Maclean Crawford

Fu-Chung Lin

Ajit N Dastane

Timothy A Stevens

Jamieson W M Crawford

Julie Ross

Ajit Dastane

The invention relates to a device and method for collecting blood whereby certain target components are isolated or removed from the blood sample at the time of collecting the blood, as well as methods for using such devices.

Devices for component removal during blood collection, and uses thereof

A container assembly for storing, treating, transporting and stabilizing a biological sample includes a container, a cap and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The sample holder includes a central cavity for receiving the sample and immersing the sample in the stabilizing agent in the container. In another embodiment, the sample holder has a closure member for closing the open top end of the cavity. The container includes a liquid reagent in an amount sufficient to treat the biological sample. The biological sample is retained in a predetermined containment area of the container to maintain the biological sample immersed in the reagent without regard to the orientation of the container.

Apparatus for transporting biological samples

A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent includes one or more protease inhibitors.

Protease inhibitor sample collection system

A collection container and a method for collecting a biological sample, particularly whole blood, that includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent includes one or more protease inhibitors.

A container assembly and method for storing, treating, transporting and stabilizing a biological sample includes a container, a closure member and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The sample holder includes a central cavity for receiving the sample and immersing the sample in the stabilizing agent in the container. The closure member includes a body member to close the top end of the central cavity of the sample holder and to limit movement of the sample holder in the container. In another embodiment, the sample holder has a closure cap for closing the open top end of the cavity. The container includes a liquid reagent in an amount sufficient to treat the biological sample. The biological sample is retained in a predetermined containment area of the container to maintain the biological sample immersed in the reagent without regard to the orientation of the container.

Method and apparatus for transporting biological samples

A container assembly for storing and stabilizing a biological sample includes a container, a closure cap and a sample holder coupled to the closure cap and removably received in the container. The sample holder can be a basket-like device coupled to an inner face of the cap and includes a central cavity for receiving the sample and immersing the sample in the reagent in the container. The closure cap includes a body member with a dimension to displace a volume of air and reduce the head space to ensure that the sample holder is completely immersed in the reagent. The sample holder has a closure member for closing the open top end of the cavity.

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Franklin Lakes, NJ, United States of America

Bruce Haywood