Beckman Coulter, Inc.

Bruce H Odegaard

Hashem Akhavan-Tafti

Renuka De Silva

Wenhua Xie

Michael Salvati

James D Mendoza

Nir Shapir

Ying Chen

Dean G Binger

Terri McLernon

Karel Z Newman, Jr

Jane A Schmidt

Godwin Orji Ogbonna

Terri Mclernon

Dean Binger

Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.

Solution phase homogeneous assays

Methods of preparing a boronate-antigen complex for immunization of animals, a monoclonal antibody specific for the same, an immunoassay method for detection of the complex and a method of calculating the amount of a target glycated protein within the sample useful in the diagnostic monitoring of diabetes are disclosed. An immunoassay kit based on this reagent is also disclosed.

Antibody against a 3-aminophenylboronic-glycated protein complex and its

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Crystal, MN, United States of America

Bruce H Odegaard