Mediquest Therapeutics, Inc.

Bruce H Devens

Mark R Burns

Maralee McVean

Kevin Kennedy

Arthur Yeung

The synthesis and use of a novel class of tumor necrosis factor (TNF&#x3b1;) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CHNH, Rand Reach is a hydrogen or a Cto Caliphatic; aliphatic amine; an alicyclic; aromatic; heterocycle; and halogenated forms thereof; and 

Immunomodulation with novel pharmaceutical compositions

The synthesis and use of a novel class of tumor necrosis factor (TNF&#x3b1;) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNF&#x3b1; and other involved cytokines. As pharmaceuticals, these compounds are used to treat inflammatory, infectious, autoimmune or other proliferative diseases and conditions related to the unwanted presence or activity of TNF&#x3b1; and/or one or more other involved cytokines, alone or in combination with other agents. Examples of compounds of the present invention are those having the structures as shown below: wherein, a, b and c may be the same or different and are integers from 0 to 12, X equals NH or CHNH, Rand Rcan be the same or different and equal to a hydrogen or a straight or branched Cto Csaturated or unsaturated aliphatic; aliphatic amine; an alicyclic; single or multi-ring aromatic; a single or multi-ring aromatic heterocycle; a single or multi-ring saturated heterocycle and the halogenated forms thereof; and

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St. Louis, MO, United States of America

Bruce H Devens