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Biovitrum Ab

Biovitrum Ab (Publ)

Bruce Fleck, Legal Representative

Magnus Cernerud

Alexander Paptchikhine

Helena Lundström

Emma Andersson

Alf Nygren

Margit Pelcman

Claes Löfström

Tom Fleck

The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R-Rare each independently selected from the group consisting of hydrogen, halogen, C-C-alkyl, C-C-alkoxy, and di-C-C-alkylamino-C-C-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.

Malate salt of (2R)-methyl-1-{3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinyl}piperazine

Stable acid addition salts of certain 2,3-disubstituted pyrazine compounds that are selective for the 5-HT2c receptor and therapeutically active in the central nervous system are described.

Phosphoric acid addition salt of (2R)-1-[3-(2-{[2-(2-dimethylaminoethoxy)-3-pyridinyl]oxy}-ethoxy)-2-pyrazinyl]-2-methylpiperazine

The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R&#x2013;Rare each independently selected from the group consisting of hydrogen, halogen, C&#x2013;C-alkyl, C&#x2013;C-alkoxy, and di-C&#x2013;C-alkylamino-C&#x2013;C-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.

Process for the preparation of stable acid addition salt of 2,3-disubstituted pyrazine compounds

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Scotts, MI, United States of America

Bruce Fleck, Legal Representative