Auburn University

Metin Colpan

Bruce F Smith

Henry J Baker

Tatiana I Samoilova

Joachim Schorr

The general field of the invention is a method for nucleic acid vaccination for animals to protect them from parvoviral infection. This invention is more particularly related to the preparation and use of parvoviral DNA and its administration to dogs, cats and mink so as to induce an immune response that can protect these animals from disease caused by virulante parvovirus. Nucleic acid immunogens are designed to include the antigenic portions of the parvoviral genome which are incorporated into bacterial plasmids. These plasmids produce the desired parvoviral gene product when introduced into host cells by transfection. Host cells transfected with the parvoviral immunogen expressing plasmids produce a stream ot antigenic proteins to which the host immune system will mount a protective immune response.

Nucleic acid vaccination for parvoviral infections

Compositions for use in targeting therapies to central nervous system (CNS) cells are provided. The compositions comprise peptides which are capable of binding CNS cells in vivo.

Methods and compositions for targeting compounds to the central nervous system

Compositions for use in targeting therapies to muscle cells are provided. The compositions comprise peptides which are capable of binding muscle cells in vivo.

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Auburn, AL, United States of America

Bruce F Smith