The Procter Gamble Company

Bruce Ernest Tepper

Mattias Schmidt

Mark James Kline

Bruno Johannes Ehrnsperger

Victor Nicholas Vega

Cornelia Sprengard-Eichel

Ramon Andres Urteaga

Ravindra Palitha Ranatunga

Donald Carroll Roe

Hui Yang

Niranjan Ramji

Constance Lee Fisher

Scott Edward Osborne

Tracey Elaine Beckman

Douglas Craig Scott

Susan Baldwin

David John Maltbie

Robert Stephen Honkonen

Wendy Qin

Mauricio Odio

The present invention relates to methods of assessing the health of skin. Biomarkers are used to evaluate skin samples. Using metabonomics approaches, samples taken from different skin sites or at different times during a treatment are used to diagnose skin conditions or to appraise various skin treatments for efficacy.

Metabonomic methods to assess health of skin

A method of controlling the spread of volatile substances is provided. The method comprises the steps of: a) impregnating a fragrance component comprising at least one PRM onto a plurality of surfaces of a sorbent to form a volatile substance-controlling composition; and b) disposing the volatile substance-controlling composition into an article wherein the fragrance component is released from the sorbent primarily in the presence of one or more volatile substances when the volatile substances are adsorbed by the sorbent.

Method of making and applying volatile substance-controlling composition

The present invention relates to a volatile substance-controlling composition comprising:

Volatile substance-controlling composition

An absorbent article which includes a phase change material capable of adding or removing heat to or from at least a portion of the absorbent article to perform a useful function on the article. The phase change material may be activated by an action of the wearer or caregiver or by environmental conditions between the article and wearer.

Absorbent article with phase change material

An absorbent article which includes a thermal cell actuator capable of adding or removing heat to or from at least a portion of the absorbent article to perform a useful function on the article. The thermal cell actuator may be activated by an action of the wearer or caregiver or by environmental conditions between the article and wearer.

Absorbent article with thermal cell actuator

The present invention relates to a method comprising subjecting a test site of a responsive system to a primary challenge; subjecting the same test site to a secondary challenge, wherein the secondary challenge is designed to enhance and/or prolong a response of the responsive system to the primary challenge, without confounding the response nor altering the mechanism by which the primary challenge elicits a response from the responsive system; and assessing the response subsequent to the secondary challenge. The methods claimed herein also preferably comprise the additional step(s) of subjecting test site(s) to one or more pre-challenge intervention(s) and/or post-challenge intervention(s) and/or concurrent-challenge intervention(s). The methods of the present invention are also useful in a study design, also claimed herein, wherein the study comprises the steps of the method outlined above in addition to comprising the steps of creating one or more controls selected from the group consisting of negative controls, primary controls, secondary controls, positive controls, and mixtures thereof. The use of the novel methods described herein often significantly shorten the duration of and/or number of subjects needed for studies aimed at understanding the etiology of a disease and/or the ability of a intervention or challenge to prevent, cure, heal, and/or reduce and/or induce damage or injury to a responsive system.

Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge

Growing community of inventors

Cincinnati, OH, United States of America

Bruce Ernest Tepper