Dionex Corporation

The Dow Chemical Company

Lee Scientific, Inc.

Bruce E Richter

Curtis D Pfeiffer

Christopher A Pohl

Hernan J Cortes

John L Ezzell

Kannan Srinivasan

Nathan L Porter

Gary L Gleave

Norman J Rothe

Brian Dorich

David W Kemp

Brett Murphy

Timothy S Stevens

Kevin Durst

Sm Rahmat Ullah

S M Rahmat Ullah

Ross A Riches

Brian A Jones

Nebojsha Avdalovic

Hernan Cortes

Gary L Gleavae

R Brent Nielsen

A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

Sample pretreatment and extraction

Methods for the solvent extraction of organic analytes from a sample are provided. An organic solvent system is used to extract analytes under elevated temperatures and pressures above 100 psi but below supercritical conditions in short times and with low amounts of solvent. The extracted organic analytes are then removed by flowing a purge fluid through the extraction cell, the cell being maintained at a constant volume throughout the extraction and purging, afterwards the analytes being analyzed.

Accelerated solvent extraction method

An apparatus for automated extraction of an analyte from a sample positioned in a sample containment cell having a fluid passageway structure for communication of an extraction fluid to and from the cavity of the cell. The apparatus includes a loading tray, an oven assembly mounted proximate the loading tray, a fluid communication assembly mounted proximate the tray, a cell manipulation assembly and a controller. The cell manipulation assembly brings an inlet conduit and an outlet conduit of the fluid communication assembly into sealed relationship with the sample containment cell and uses the conduits to pick up and move the cell to and from the cell tray and oven assembly. The fluid communication assembly further causes flow of an extraction fluid into the cell and pressurizes the cell for extraction of an analyte from the sample under elevated temperatures and pressures, which can be under supercritical conditions for supercritical fluid extraction but preferably are below supercritical conditions for solvent extraction. The apparatus and method include a solvent extraction soak, purging of the extracted fluid, flushing with a gas and rinsing so as to avoid contamination of subsequent analyte extractions.

Automated accelerated solvent extraction apparatus and method

Automated analyte supercritical fluid extraction apparatus

Apparatus and method for on-line coupled liquid chromatography and gas chromatography analysis. The system includes a high-volume, liquid vaporizing chamber, or interface capillary tube which allows injection of a substantial volume of sample-carrying eluent and concentrates bands, obviating adverse effects on the resolution or peak shape of the components of interest. The vaporizing chamber is interposed between a packed or wall-coated open tubular capillary liquid chromatographic column and a capillary gas chromatographic column. The capillary liquid chromatographic column permits the use of small volumes of eluent and reduced flow rates.

On-line coupled liquid and gas chromatography system with an interface

An apparatus for receiving chemical compounds carried in a high pressure effluent fluid stream from supercritical fluid extraction. The apparatus includes a heated conduit connected to supercritical fluid extraction device through which an effluent stream flows. The exit port of the heated conduit is located within the airspace of a decompression zone which is free of liquid. A liquid solvent chamber is provided in open communication with the downstream end of the decompression zone into which the effluent stream flows for the recovery of chemical compounds therein.

Supercritical fluid extraction restrictor and collection system

Apparatus and method for on-line coupled liquid chromatography and gas chromatography analysis includes a retention gap which allows injection of a substantial volume of sample-carrying eluent and concentrates bands, obviating adverse effects on the resolution or peak shape of the components of interest. The retention gap is used to simultaneously receive and vaporize liquid solvent in a manner highly suitable for purposes of gas chromatographically separating solutes of interest dispersed in the liquid chromatography solvent.

On-line coupled liquid and gas chromatography system

Porous ceramic plugs are cast in place in chromatographic columns in order to provide supports for chromatographic beds in liquid chromatography devices and restrictors in supercritical fluid chromatographic devices. The supports are cast in place by fusing a silicate containing solution, such as one containing potassium silicate, which has been drawn into the outlet end of the column.

Chromatography columns with cast porous plugs and methods of fabricating

Growing community of inventors

Sandy, UT, United States of America

Bruce E Richter