Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

Mcneil Ab

Ortho Pharmaceutical Corporation

Other

The Scripps Research Institute

Millennium Pharmaceuticals Limited

Mcneil Laboratories, Incorporated

Mcneil-ppc, Inc.

Janssen Pharmaceutica

Advanced Technologies and Regenerative Medicine, LLC

Oxis International, Inc.

Ortho-mcneil-janssen Pharmaceuticals, Inc.

Ethicon, Gmbh

Bruce E Maryanoff

Han-Cheng Zhang

David F McComsey

Hong Ye

William Joel Hoekstra

Michael J Costanzo

Kimberly White

William Alvin Kinney

Bruce Ray Conway

Michael Nicholas Greco

Michael Hawkins

Keith T Demarest

Allen B Reitz

Leonard Robert Hecker

Edward Charles Lawson

Shyamali Ghosh

Gee-Hong Kuo

Diane K Luci

Lan Shen

Stephen C Yabut

David John O'Neill

Samuel O Nortey

Alexey Borisovich Dyatkin

Cynthia Anne Maryanoff

Robert E Boyd

Jay M Matthews

Kirk L Sorgi

Winston Z Ho

Eugene Powell

Cailin Chen

Robert M Scarborough

Anjali Pandey

Li Liu

Philip J Rybczynski

Ahmed F Abdel-Magid

Mona Patel

Bart L De Corte

Min Amy Xiang

Brett A Tounge

Joseph F Gardocki

Michael H Parker

Steven Mehrman

Joseph Gunnet

Lawrence De Garavilla

Richard Look

Peter J Connolly

Alan Deangelis

John R Carson

William V Murray

Wei He

James J McNally

Frank John Villani, Jr

Robert H Chen

Jonathan Alan Medlock

Christopher A Teleha

Catherine P Prouty

Chunlin Yang

Antonio Zanotti-Gerosa

Michael G Goodman

Virginia L Smith-Swintosky

Francois M Sommen

Richard P Shank

M Reza Ghadiri

Sergey Sviridov

Cheryl P Kordik

Claudia K Derian

Thomas Matalenas

Mabel Alarnino Cejas

David Fred McComsey

Ellen W Baxter

Michael J Costenzo

Daniel B Cawley

Kenneth J Stenglein

Albert J Molinari

Ghosh Shyamali

Luke J Leman

Gabriela Grasa

Yannan Zhao

Nikolay Marchenko

Llorente Vincente R Bonaga

Han Cheng Zhang

Chandra R Shah

Alen B Reitz

Michael N Parker

William J c/o Ortho-Mcneil Pharmaceutical Inc Hoekstra

Min A Xiang

Mabel Alamino Cejas

Michael J Hawkins

The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.

Uses of cyclic peptides for treating and preventing atherosclerosis

The present invention is directed to compounds of formula (I) 

Urotensin II receptor antagonists

The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.

Co-therapy for the treatment of epilepsy and related disorders

The invention is directed to benzo[1,4]oxazin-3-one, benzo[1,4]thiazin-3-one and quinolin-2-one Urotensin II receptor antagonists useful in treating or ameliorating a Urotensin-II mediated disorder. More specifically, the present invention relates to certain novel benzo[1,4]oxazin-3-one, benzo[1,4]thiazin-3-one and quinolin-2-one compounds and methods for preparing compounds, compositions, intermediates and derivatives thereof. Pharmaceutical compositions and methods for treating or ameliorating a Urotensin-II mediated disorder using compounds of the invention are also described.

Benzo[1,4]oxazin-3-one, benzo[1,4]thiazin-3-one and quinolin-2-one urotensin II receptor antagonists

The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.

Enantioselective process for preparing a substituted alkanoic acid

The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.

2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist

The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17: 

Method of treating asthma

The present invention is directed to a compound of Formula (I): or a form thereof, wherein X, X, X, X, R, Rand Rare as defined herein, useful as tryptase inhibitors.

Spiropiperidines for use as tryptase inhibitors

The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.

The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein X, X, R, R, Rand Rare as defined herein, and their methods of preparation and use as ADP inhibitors.

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The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated disorder.

Piperidinyl compounds that selectively bind integrins

The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.

Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders

The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.

Collagen-related peptides and uses thereof

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Forest Grove, PA, United States of America

Bruce E Maryanoff