Children's Hospital

Bruce E Kari

Richard C Gehrz

Nancy O Lussenhop

Glycopeptides of human cytomegalovirus have been isolated and purified. These glycopeptides and antibodies reactive with them are useful in diagnosis and therapy.

Immunogenic glycoproteins of human cytomegalovirus

Substantially-pure immunogenic glycoprotein complexes of the gCII family, and constituent glycoproteins which can be derived from the membrane envelope of human cytomegalovirus are provided.

Immunogenic glycoproteins of human cytomegalovirus gCII

The present invention is directed to a composition containing a first monoclonal antibody, capable of neutralizing human cytomegalovirus (HCMV), that binds to a first epitope on HCMV GCA, and a second non-neutralizing HCMV monoclonal antibody that binds to a second epitope on HCMV GCA. The GCA complex includes antigenically-related glycoproteins of molecular weights 130,000, 93,000, and 50,000-52,000 kDa. The mixture of the two antibodies has greater neutralizing activity than a composition containing the first antibody alone. Also provided is a method for neutralizing the infectivity of HCMV using the composition.

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Minneapolis, MN, United States of America

Bruce E Kari