Eli Lilly and Company

Bruce D Gitter

Philip Arthur Hipskind

J Jeffry Howbert

Brian Stephen Muehl

Thomas Alan Crowell

Joseph H Krushinski, Jr

Karen Lynn Lobb

James Arthur Nixon

Sung Y Cho

William H Lunn

Smriti Iyengar

Rachelle Jeanette Galvin

This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.

Non-peptide tachykinin receptor antagonists

Piperidinyl and piperazinyl tachykinin receptor antagonists

Hexamethyleneiminyl tachykinin receptor antagonists

The present invention provides methods of treating or preventing conditions associated with a lack of parathyroid hormone comprising administering to a mammal in need thereof an effective amount of a compound having activity as a tachykinin receptor antagonist. In a most preferred embodiment the present invention provides methods of increasing bone growth in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a tachykinin receptor antagonist. Another embodiment of this invention provides methods of treating hyperparathyroidism in a mammal comprising administering to a mammal in need thereof an effective amount of a compound having activity as a tachykinin receptor antagonist.

Methods of treating bone loss

Methods of treating or preventing sleep apnea

This invention encompasses methods for the treatment or prevention of a physiological disorder associated with an excess of tachykinins, which method comprises administering to a mammal in need of said treatment an effective amount of a compound of Formula I ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamthylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

Non-peptide tachykinin receptor antagonists to treat psycological

This invention encompasses methods for the treatment or prevention of a physiological disorder associated with an excess of tachykinins, said disorder being an allergy which method comprises administering to a mammal in need of said treatment an effective amount of a compound of Formula I ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamthylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

Non-peptide tachykinin receptor antagonists to treat allergy

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Carmel, IN, United States of America

Bruce D Gitter