Collagen Corporation

Alza Corporation

Harvard College

Bruce B Pharriss

George H Chu

Thomas L Smestad

Diana M Hendricks

Karl A Piez

Ross R Erickson

Stephen A Tillson

Patrick S Wong

Donald G Wallace

Howard Palefsky

William G Braun

Julianne Glowacki

Hertsel Reihanian

A human placental collagen composition for use in soft tissue augmentation comprising an aqueous suspension of a homogenized nonirradiation-sterilized mixture of type I and type III human placental collagen, wherein the type III collagen constitutes less than about 10% by weight of the mixture.

Composition of low type III content human placental collagen

Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.

Calcium phosphate/atelopeptide collagen compositions for bone repair

A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.

Xenogeneic collagen/mineral preparations in bone repair

A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.

Method of making molds with xenogeneic collagen/mineral preparations for

Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.

Injectable implant composition having improved intrudability

A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.

A plastic dispersion of demineralized bone powder and reconstituted native atelopeptide collagen fibers in a continuous aqueous phase having a substantially physiologic pH and ionic strength is used to repair or construct bone by injecting or implanting it at the repair or construction site. Once emplaced the dispersion induces rapid and complete osteogenesis at the site.

Osteogenic composition and method

A delivery system is disclosed. The system is useful for the preprogrammed, unattended delivery of at least one beneficial agent to a pre-selected environment of use. The system comprises (I), a beneficial agent (II), a delivery module comprising, (a) a closed tubular member twined about itself to form a multiplicity of continuous, entwined, mated members, the members having, (b) an internal reservoir for storing agent in an amount for execution of the program, (c) a rate controller which maintains the rate of agent delivered in an effective amount from the members throughout the life of the system, (d) an energy source for transferring agent from the reservoir to the environment, and, (e) a portal for releasing agent from the members to the environment, (III), a platform which integrates the module into a unit sized, shaped and adapted for insertion and retention in the environment, and, (IV) a program which provides for the controlled release of agent to produce the desired beneficial effect over a prolonged period of time.

Delivery system with mated members for storing and releasing a plurality

A method for treating dysmenorrhea is disclosed. The method comprises administering to the uterus of a warm blooded animal having dysmenorrhea controlled and continuous low dosage amounts of a progestational hormone to impart symptomatic relief from dysmenorrhea.

Method for treating dysmenorrhea with a uterine therapeutic system

A method for treating hypermenorrhea is disclosed. The method comprises continuously administering controlled low dosage amounts of a progestational hormone to the uterus to impart relief from hypermenorrhea.

Growing community of inventors

Palo Alto, CA, United States of America

Bruce B Pharriss