Ici Australia Limited

Bruce Adam Forsyth

Errol J McGarry

Richard B Warner

Donald William Harney

Colin Wilshire

David Ernest Pryor

Keith G Watson

Alexander Serban

George Richard Birchall

Errol-James McGarry

The invention concerns a process for killing internal parasites, especially trematodes or nematodes, affecting warm blooded animals such as cattle, sheep and goats by administering an effective amount of a composition containing as active ingredient a compound of the formula ##STR1## Certain of the compounds of formula I are novel and in further embodiments the invention provides novel compounds and compositions for use in the process of the invention. The process of the invention is especially applicable to the tretment of warm blooded animals infected with the trematodes Fasciola hepatica (liver fluke).

5-Substituted pyrimidine derivatives active against internal animal

A process for killing internal parasites of warm blooded animals which process comprises treating the infected animal with an effective amount of a composition comprising as active ingredient a compound of the general formula I: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, lower alkenoyl, aroyl or CH.sub.2 COOR.sup.4 wherein R.sup.4 is hydrogen or lower alkyl; B, C and D, which may be the same or different, are halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR.sup.5 wherein R.sup.5 is hydroxy, lower alkoxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7, which may be the same or different, are hydrogen or lower alkyl; A, E, X, Y and Z, which may be the same or different, are hydrogen, halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR.sup.5 wherein R.sup.5 is as hereinbefore defined; J and G, which may be the same or different, are hydrogen, lower alkyl, optionally substituted aryl, cyano, nitro or trichloromethyl or, together with the geminal hydrogen, the group .dbd.CCl.sub.2 ; or an optical isomer thereof; or a salt thereof; and wherein lower alkyl and lower alkoxy are defined as groups containing from 1 to 6 carbon atoms, lower alkenyl and lower alkanoyl are defined as groups containing from 2 to 6 carbon atoms and lower alkenoyl is defined as a group containing from 3 to 6 carbon atoms; and an inert carrier therefor.

2,6-Benzyl substituted phenols

A method for killing internal parasites of warm blooded animals by treating the animals with an effective amount of a composition comprising a bis-(2-hydroxy-3-nitrophenyl)methane derivative; and novel bis(2-hydroxy-3-nitrophenyl)methane derivatives.

Process for killing internal helminths using certain

Treatment of animals with 2,6-bis(2-hydroxybenzyl)phenols to eradicate

A compound of the general formula I ##STR1## wherein R.sup.1 is halogen, R.sup.4 is a highly branched alkyl group, R.sup.2 and R.sup.3 which may be the same or different are hydrogen or halogen atoms or lower alkyl groups.

Compositions for killing internal parasites containing

A composition of matter for treating warm-blooded animals to eradicate internal parasites comprising a compound chosen from the group consisting of

Compositions containing certain 2,4-halo-6-nitrophenols or derivatives

A method of treating warm blooded animals to eradicate certain internal parasites; which method comprises administering to said warm blooded animals a therapeutic dose of a composition comprising as active ingredient a compound of formula I. ##EQU1## wherein R.sup.1, R.sup.2 and R.sup.3 which may be the same or different are hydrogen, or halogen and at least two of R.sup.1, R.sup.2, and R.sup.3 are halogen, and R.sup.4 and R.sup.5 which may be the same or different are selected from the group consisting of hydrogen, alkyl containing from 1 to 6 carbon atoms, --NHR.sup.6 where R.sup.6 is hydrogen or an alkyl group containing from 1 to 6 carbon atoms; and when either R.sup.4 or R.sup.5 is --NHR.sup.6 then R.sup.5 or R.sup.4 respectively is hydrogen.

Halomethanesulfonamides for eradicating internal parasites

A method of killing internal parasites in warm blooded animals comprising administering orally or parenterally to an infected animal an effective amount of a compound of the formula: ##SPC1## Where R.sup.1 is hydrogen or acetyl, R.sup.2 is hydrogen, acetyl or lower alkyl, X.sup.1 and X.sup.2 are iodine atoms; X.sup.3, X.sup.4, X.sup.5 and X.sup.6 which may be the same or different are chlorine, bromine, iodine, trifluoromethyl or hydrogen; at least two and not more than two of X.sup.3, X.sup.4, X.sup.5 and X.sup.6 are hydrogen; when X.sup.3 is chlorine, bromine, iodine or trifluoromethyl, then X.sup.4 and X.sup.6 are both hydrogen; and at least one of X.sup.3, X.sup.4, X.sup.5 and X.sup.6 is trifluoromethyl, said compound being administered in a dosage amount of from 1 to 50 mg active ingredient/Kg animal bodyweight.

Method of killing internal parasites using salicylanilides

A method of treating warm blooded animals to eradicate certain internal parasites; which method comprises administering to said warm blooded animals a therapeutic dose of a composition comprising as active ingredient a compound of formula I ##EQU1## wherein X is halogen, and R.sup.1 and R.sup.2 which may be the same or different are selected from the group consisting of hydrogen, alkyl containing from 1 to 6 carbon atoms, -- NHR.sup.3 where R.sup.3 is hydrogen or an alkyl group containing from 1 to 6 carbons atoms; and when either R.sup.1 or R.sup.2 is -- NHR.sup.3 then R.sup.2 or R.sup.1 respectively is hydrogen.

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Croydon, Australia

Bruce Adam Forsyth