Dewpoint Therapeutics, Inc.

Bruce Aaron Beutel

Mark Andrew Murcko

Stephen Paul Hale

Diana Maria Mitrea

Ina Poser

Peter Jeffrey Dandliker

Alexander Szewczak

Edgar Erik Boczek

Matthäus Mittasch

Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided.

Methods of screening for condensate-associated specificity and uses thereof

Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.

Methods of characterizing condensate-associated characteristics of compounds and uses thereof

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Needham, MA, United States of America

Bruce Aaron Beutel