Immunex Corporation

Bruce A Mosley

David J Cosman

M Patricia Beckmann

Carl J March

Linda S Park

Rejean Idzerda

John Ernest Sims

Steven K Dower

Stephen D Lupton

Methods and comnositions related to antibodies that bind to mammalian Tnterleulcin-4 recentor proteins are disclosed.

Antibodies to Interleukin-4 receptors and uses thereof

Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

Antibodies to interleukin-4 receptors and uses thereof

Interleukin-4 receptors

A novel polypeptide functions as the &bgr; chain of an oncostatin M receptor and is thus designated OSM-R&bgr;. Heterodimeric receptor proteins comprising OSM-R&bgr; and gp130 bind oncostatin M and find use in inhibiting biological activities mediated by oncostatin M.

DNA encoding a receptor subunit for oncostatin M

Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.

Type II Interleukin-1 receptors

DNA encoding type II IL-1 receptors

DNA encoding interleukin-4 receptors

A novel polypeptide functions as the .beta. chain of an oncostatin M receptor and is thus designated OSM-R.beta.. Heterodimeric receptor proteins comprising OSM-R.beta. and gp130 bind oncostatin M and find use in inhibiting biological activities mediated by oncostatin M.

Receptor for oncostatin M

Antibodies to receptor for oncostatin M

Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed. Also disclosed are compositions and methods for regulating an IL-1 mediated immune or inflammatory response in a mammal.

Soluble type II interleukin-1 receptors and methods

Mammalian Interleukin-4 receptor proteins find use in inhibiting biological activities of IL-4. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

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Seattle, WA, United States of America

Bruce A Mosley