The General Hospital Corporation

Bruce A Morgan

Robert E Burgeson

Jiro Kishimoto

Katia Georgopoulos

David Enshell-Seijffers

Clair Kelley

The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.

Methods of culturing dermal papilla cells

Methods and compositions for identifying and isolating dermal papilla cells are described. DP cells can be identified based on corin expression. Isolated DP cells can be used, e.g., to modulate hair growth.

Methods of isolating dermal papilla cells

Methods of identifying dermal papilla cells

Provided herein are (a) Aiolos gene, Aiolos polypeptides, Aiolos homodimers, Aiolos/Ikaros heterodimers and methods of using Aiolos nucleic acids and polypeptides; (b) Helios gene, Helios polypeptides, Helios homodimers, Helios/Ikaros heterodimers, Helios/Aiolos heterodimers, and methods of using Helios nucleic acids and polypeptides; (c) Daedalos nucleic acids, Daedalos polypeptides, and other related molecules and methods of making and using the same; and (d) Ikaros regulatory elements and uses thereof.

Aiolos, Helios, Daedalos and Ikaros: genes, polypeptides, regulatory elements and uses thereof

Methods of modulating hair growth

The invention features an Aiolos protein, and nucleic acid sequence encoding such protein. The invention also features methods of making and using an Aiolos protein, and methods of obtaining an antibody from an animal having an Aiolos deregulated cell.

Aiolos gene

The invention provides Daedalos polypeptides, nucleic acids encoding Daedalos polypeptides, and methods of using Daedalos polypeptides and nucleic acids. Also included in the invention are methods of diagnosis, methods of treatment, methods of detection, and methods of controlling neural cell differentiation by detecting and/or modulating expression of Daedalos in a cell.

Method of identifying a neural progenitor cell by evaluating expression of daedalos

An Aiolos protein. The prior sentence is the abstract. Print as is and delete this message.

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Lexington, MA, United States of America

Bruce A Morgan