University of Pittsburgh

The Uab Research Foundation (the University of Alabama at Birmingham)

University of Oregon

University College Cardiff Consultants Limited

Morehouse School of Medicine

Duke University

Other

Complexa Inc.

Aeolus Pharmaceuticals, Inc.

Bruce A Freeman

Francisco Jose Schopfer

Bruce Branchaud

Yuqing E Chen

Paul Baker

Valerie O'Donnell

James D Crapo

Brian J Day

Irwin Fridovich

Tim D Oury

Rodney J Folz

Michael Peter Trova

Ines Batinic-Haberle

Marco Fazzari

William Richard Wagner

Nicholas Khoo

Carola Neumann

Steven Woodcock

Antonio DAmore

Francisco J Schopfer

A method comprising co-administering to a subject having cancer, suspected of having cancer, or at risk of developing cancer:

Electrophiles and electrophile pro-drugs as RAD51 inhibitors

Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, R, R, R, R, R, and Rare defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.

Fatty acids as anti-inflammatory agents

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include dicarboxylic acid compounds containing electron withdrawing groups, alkyl esters of dicarboxylic acids containing electron withdrawing groups, or compounds of Formulae I to X. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

Prevention, treatment and reversal of disease using therapeutically effective amounts of dicarboxylic acid compounds

A construct comprising a dermal extracellular matrix gel, polymer fibers, and microparticles containing a nitro oleic acid agent.

Nitro-oleic acid controlled release platform to induce regional angiogenesis in abdominal wall repair

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions

Nitro oleic acid and related metabolites are agonists of PPAR-&#x3b3;. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-&#x3b3;, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-&#x3b3;.

Nitrated-fatty acids modulation of type II diabetes

Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, R, R, R, R, and Rare defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.

Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.

Reversibly protected thiolated electrophilic fatty acids as prodrugs

Described herein are nitrated lipids and methods of making and using the nitrated lipids.

Nitrated lipids and methods of making and using thereof

Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.

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Pittsburgh, PA, United States of America

Bruce A Freeman