Bristol-myers Squibb Compnay

Bristol-myers Company

Bruce A Bonenberger

Claude E Gallian

Robert J Bequette

John R Reckelhoff

A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.

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Evansville, IN, United States of America

Bruce A Bonenberger