Other

Novavax Ab

Mx Adjuvac Ab

Isconova Ab

British Technology Group Limited

Duecom

Iscotec A.b.

Erasmus University Rotterdam Medical Center

3nine Ab

Canqura Oncology Ab

Bror Morein

Karin Lovgren Bengtsson

Jill Ekstrom

Karin Lövgren Bengtsson

Saideh Berenjian

Katarina Ranlund

Kefei Hu

Kafei Hu

Albertus D M E Osterhaus

Birgitta Fromgren

Karin Lovgren-Bengtsson

John Cooper Cox

Jan Thurin

Carlos Concha Baschunan

Göran Friman

Alan Robert Coulter

Bo Sundquist

Nils-Gunnar Ilbäck

Kristian Dalsgaard

Karin Lovgren

Karin L Ovgren

Jill Ekström

Carlos Concha Bascunan

Karin Lövgren-Bengtsson

Karin Bengtsson LÖVGREN

ADME Osterhaus

Carlos Baschunan

Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, block polymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A, CpG variants, CT and LT or fractions thereof.

Quil A fraction with low toxicity and use thereof

Iscom particles can be used as an adjuvant for preparing of an antigenic composition which comprises live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A composition may comprise at least one iscom particle and one or more live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A kit can comprise at least one compartment containing at least one living organism and at least one compartment containing at least one iscom particle.

Composition comprising iscom particles and live micro-organisms

The present invention relates to a composition comprising at least one ISCOM complex and at least one ectodomain from at least one hemagglutinin (HA) domain and at least one ectodomain from at least one neuraminidase (NA) domain from one or more influenza virus, wherein the extodomains represent ectodomains isolated from the influenza virus. The invention also regards a kit. The composition may be used as an immune stimulating medicine, immune modulating pharmaceutical or a vaccine e.g. against influenza for vertebrates, e.g. birds and mammals.

Influenza vaccine

The invention relates to a composition comprising a mixture of at least two iscom complexes each complex comprising essentially one saponin fraction fromMolina. The complexes may be iscom complexes or iscom matrix complexes. The invention also pertains to the use of such a mixture for the preparation of an immunomodulating pharmaceutical, and adjuvant, formulations for immunization, e.g. for production of monoclonal antibodies, and a vaccine. Kits of parts comprising at least two parts, wherein each part comprises one iscom complex or one iscom matrix complex according to the invention are also embraced.

ISCOM preparation and use thereof

The present invention regards nanoparticles comprising a sterol and a component derived fromMolina selected fromacid andsaponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in fields of medicine including cancer treatment and food related compounds

The present invention regards nanoparticles comprising a sterol and a component derived fromMolina selected from quillaja acid andsaponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nano particles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

The present invention regards nanoparticles comprising a sterol and a component derived fromselected fromacid andsaponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

A nanoparticle comprising at least one sterol, e.g. cholesterol and a component fromMolina (QuilQ) selected fromsaponin, characterized in that said nanoparticles do not comprise a phospholipid and in that the sterol molecule is bound by a hydrophobic bond between a hydroxyl group of the sterol and terpene moieties in a Quil A micelle and by an hydrophilic ester bond between a sterol OHand COOHor aldehyde groups in the QuilA micelle. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

[object Object]

Compositions comprising iscom particles and live micro-organisms

A method for capturing airborne agents or products of agents, such as microorganisms, including viruses, and microbial antigens, toxins and allergens, comprising the formation of at least one curtain of charged particles in the form of an emulsion, a suspension or an aerosol, constantly renewing and regenerating said at least one curtain, and passing air containing airborne agents through said at least one curtain, which acting as a filter captures said agents; as well as a particle formulation for performing the method, comprising any charged particles dispersed in a liquid, including lipid-containing particles, e.g. in the form of an emulsion, or micelles, or lipid-containing particles in the form of an aerosol, or any other charged airborne particles in an aerosol.

Method and a filter for capturing airborne agents

The present invention relates to the use of lipid containing particles, such as liposomes, iscom and/or iscom matrix and posintros, comprising at least one lipid and at least one saponin for the preparation of a pharmaceutical for the treatment of cancer. The saponins are preferably fromMolina. Further, the particles are also delivery systems for one or several compounds for cancer treatment with complementary mechanisms. More, the invention discloses kit of parts comprising at least two parts, wherein one part comprising at least one saponin fraction which is hydrophobic having a killing effect on cancer cell; and the other part comprising at least one saponin fraction which is comparatively hydrophilic, stimulating and modulating the immune response.

Use of lipid containing particles comprising Quillaja saponins for the treatment of cancer

Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, blockpolymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A. CpG variants, CT and LT or fractions thereof.

The present invention relates to a composition comprising at least one fibronectin binding protein, and/or at least one a truncated fibronectin binding protein and/or at least one fibronectin binding peptide, all comprising at least one fibronectin binding domain; and at least one iscom matrix complex and/or liposome and/or at least one lipid and at least one saponin, whereby the at least one lipid and the at least one saponin may be in complex, solution or suspension. Further, it regards use thereof for the preparation of a vaccine against a micro organism that comprises at least one fibronectin binding domain. It also relates to a kit of parts comprising at least two compartments, wherein one compartment comprises at least one truncated fibronectin binding protein and/or a fibronectin binding peptide, that comprises at least one fibronectin binding domain, and another compartment comprises an instruction for use and/or an iscom matrix complex and/or an iscom complex and or a liposome. Further it relates to a method for vaccination of an individual.

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Uppsala, Sweden

Bror Morein