Aktiebolaget Draco

Aktiebolaget Astra

Astra Aktiebolag

Bror Arne Thalen

Ralph Lennart Brattsand

Bengt I Axelsson

Jan W Trofast

Paul H Andersson

Per T Andersson

Peter Edman

Stinabritt Nilsson

Thomas Hogberg

Jan Erik Ulmius

Leif Arne Kallstrom

Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula

Colon or ileum-specific glucocorticosteroid derivatives

Colon or ileum-specific steroid derivatives

The invention concerns compounds of formula I ##STR1## in which R.sub.1 is hydrogen or a straight or branched hydrocarbon chain; R.sub.2 is hydrogen or a straight or branched hydrocarbon chain; R.sub.3 is acyl; X.sub.1 is hydrogen, fluorine or chlorine; and X.sub.2 is hydrogen, fluorine or chlorine. Also disclosed are processes for preparation of the compounds, pharmaceutical compositions containing them and methods employing the compounds in the treatment of inflammatory and allergic conditions.

Steroid esters

The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula R.sub.1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms. The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.

16,17-acetalsubstituted pregnane 21-oic acid derivatives

The invention refers to compounds having anti-inflamatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bond

16,17-acetalsubstituted androstane-17.beta.-carboxylic acid esters

The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents in the carbon atom at position 20, in which formula the 1,2 position is saturated or is a double bond,

Novel androstane-17.beta.-carboxylic acid esters, a process and

The invention refers to compounds having anti-inflammatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula X.sub.1 represents a hydrogen, chlorine, bromine or fluorine atom;

Novel androstane-17.beta.-carboxylic acid esters

The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon atom in position 22, in which formula A is n-propyl or n-butyl and Z is hydroxyl or hydroxyl esterified with a fatty acid with a straight or branched hydrocarbon chain having 1-5 carbon atoms. The invention also refers to a process for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment and control of inflammatory conditions.

Growing community of inventors

Bjarred, Sweden

Bror Arne Thalen