Non-invasive Technology Inc.

Nim, Inc.

Other

University of Pennsylvania

Baylor College of Medicine

Performance Predictions, Inc.

Infrascan, Inc.

Non-invasivie Technology, Inc.

Britton Chance

Hanli Liu

David Alan Boas

Arjun Gaurang Yodh

Gang Zheng

Claudia S Robertson

John R Sorge

Maureen O'Leary

John S Leigh

Baruch Ben Dor

Edward James Delikatny

Shoko Nioka

Jian Weng

Kenneth J Kaufmann

Qingming Luo

Victor Legallais

Jerry P Glickson

Norman C Graham, Jr

Scott M Eleff

Klara Stefflova

Jerry D Glickson

Xingde Li

Juan Chen

Vasilis Ntziachristos

Claudia Robertson

A system for examining biological tissue of a subject includes a wireless optical probe, electronics and a processor. The wireless optical probe includes a light source connected to receive signals from a wireless receiver, and a light detector coupled to provide data to a wireless transmitter constructed to transfer data wirelessly. The wireless optical probe is powered by a battery. The light source is constructed and arranged to introduce optical radiation in the visible to infra-red range into the examined biological tissue of a subject, and the light detector is constructed and arranged to detect radiation that has migrated in the examined biological tissue of the subject. The electronics is constructed and arranged to communicate wirelessly with the optical probe, to store the transferred data, and to create optical data. The processor is constructed and arranged to evaluate the optical data. The system may also provide brain stimulation and evaluate the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect 'deceit.' In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.

Examination and imaging of brain cognitive functions

The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for their use. More particularly, the present invention relates to photodynamic therapy agents. The invention further relates to methods for decontaminating blood and methods for treating cancer or viral infection in a subject using the conjugates of the present invention.

Activatable photodynamic therapy agents

A system and method for determining brain hematoma including a handheld device for emitting and detecting radiation with a removable light guide assembly. A method for determining a brain hematoma condition that includes determining optical density of various regions of the brain using near infrared spectroscopy.

System and method for detection of hematoma

A system and method for examining or imaging brain functions of a subject includes a light source and a light detector located on the exterior surface of the subject's head. The light source introduces transcranially optical radiation into the brain of a subject, and the light detector detects radiation that has migrated in a brain region from the light source to the detector. The system also provides brain stimulation and evaluates the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect 'deceit.' In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.

The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

Antineoplastic agents targeted via glut transporters

An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam, transmitted to the biological tissue, spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons) from the photons that have migrated in the examined tissue. The system prevents detection of the 'noise' photons by the light detector or, after detection, eliminates the 'noise' photons in the detected optical data used for tissue examination.

Optical examination of biological tissue using non-contact irradiation and detection

An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam to be transmitted to the biological tissue spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined biological tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons, i.e., 'noise' photons) from the photons that have migrated in the examined biological tissue. This system prevents detection of the 'noise' photons by the light detector or, after detection, eliminates the &#x201c;noise&#x201d; photons in the detected optical data used for tissue examination.

Examination of biological tissue using non-contact optical probes

An optical examination technique employs an optical system for in vivo non-invasive examination of breast tissue of a subject. The optical system includes an optical module, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.

Detection, imaging and characterization of breast tumors

An optical examination technique employs an optical system for in vivo non-invasive transcranial examination of brain tissue of a subject. The optical system includes an optical module arranged for placement on the exterior of the head, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.

Optical system and method for in-vivo transcranial examination of brain tissue of a subject

Methods and systems are described that examine tissue positioned between input ports and a detection port. At lease one source of a visible or infrared wavelength is provided that introduces electromagnetic radiation into the subject. The detection port is optically coupled to a detector that is connected to a detector circuit. Radiation intensities are selected for introduction at the input ports to define a null plane in the tissue. The detection port is positioned relative to the null plane. Radiation is introduced into the subject at the first input port and the radiation that migrates through the tissue is detected. The detector circuit stores a first detector signal corresponding to the first detected radiation. Radiation is introduced at the second input port and is detected. The first detector signal is subtracted from a second detector signal corresponding to the second detected radiation to obtain processed data.

Optical techniques for examination of biological tissue

A spectroscopic method and system for examination of biological tissue includes multiple input ports optically connected to at least one light source, multiple detection ports optically connected to at least one detector, a radiation pattern controller coupled to the light source and detector, and a processor. The multiple input ports are arranged to introduce light at input locations into biological tissue and the multiple detection ports are arranged to collect light from detection locations of the biological tissue. The radiation pattern controller is constructed to control patterns of light introduced from the multiple input ports and constructed to control detection of light migrating to the multiple detection ports. The processor is operatively connected to the radiation pattern controller and connected to receive detector signals from the detector, and is constructed to examine a tissue region based on the introduced and detected light patterns.

Examination of subjects using photon migration with high directionality techniques

This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system () containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).

Examination of scattering properties of biological tissue

An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.

Sensing and interactive drug delivery

A cognition spectrophotometer system for transcranial brain examination using electromagnetic radiation of a visible or infrared wavelength includes an optical unit, a stimulation module, a remote communication unit, and a processor. The optical unit includes a light source adapted to introduce transcranially from an input port, placed at a input location on the exterior of the head, electromagnetic radiation of the wavelength into the brain, and a light detector adapted to detect, at a detection port placed at a detection location on the exterior of the head, radiation that has migrated in the brain. The stimulation module is constructed and arranged to cause stimulation of a brain activity while introducing the radiation at the input port. The remote communication unit includes a transmitter and a receiver. The processor adapted to process signals of the detected radiation that has migrated in the brain to create processed data and determine a characteristic of the brain activity by correlating the processed data to the caused stimulation of the brain activity, wherein the processor is constructed to provide the processed data reflecting a difference between stimulated and non-stimulated tissue.

Transcranial examination of the brain

A pathlength corrected spectrophotometer for tissue examination includes an oscillator for generating a carrier waveform of a selected frequency, an LED light source for generating light of a selected wavelength that is intensity modulated at the selected frequency introduced to a subject, and a photodiode detector for detecting light that has migrated in the tissue of the subject. The spectrophotometer also includes a phase detector for measuring a phase shift between the introduced and detected light, a magnitude detector for determination of light attenuation in the examined tissue, and a processor adapted to calculate the photon migration pathlength and determine a physiological property of the examined tissue based on the pathlength and on the attenuation data.

Growing community of inventors

Marathon, FL, United States of America

Britton Chance