University of California

California Institute of Technology

Brittany D Needham

Paul H Patterson

Sarkis K Mazmanian

Elaine Y Hsiao

Michael A Fischbach

Masanori Funabashi

Gil Sharon

Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease

Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease

Growing community of inventors

Pasadena, CA, United States of America

Brittany D Needham