Novartis Ag

Solvias Ag

Brigitte Monika Cron-Eckhardt

Fritz Blatter

Martin Szelagiewicz

Claudia Marcolli

Urs Christoph Hofmeier

Susanne Christine Wieland-Berghausen

Ferenc Jozsef Rakoczi

Peter Koller

The provision of animal feed pellets is described, which pellets comprise, as antibiotic, a pleuromutilin derivative is stabilized form, namely in the form of microspherules. The pleuromutilin derivatives in question have the general formula (I) wherein Ris ethyl or vinyl, there is either a double bond or a single bond between carbon atoms 1 and 2, Ra and Rb are each independently of the other hydrogen or halogen, and T is a short or long-chain organic radical. 

Microspherules containing a pleuromutilin derivative

A device includes a support () and at least two seals (), which are arranged in a row and are hermetically fitted into cavities, and protrude from the support laterally with respect to inlet and outlet openings, one end of the support being provided with an inlet opening () and one end being provided with an outlet opening (), and the seals being provided with a least one inlet opening and one outlet opening, and the support containing at least one first channel () which starts at the inlet opening () and is continuous, and is arranged in such a way that it opens into the inlet openings in the side walls of the seals arranged in a row, and one second channel () which starts at the outlet opening and is continuous, and is arranged in such a way that it opens into the outlet openings in the side walls of the seals arranged in a row. The system is suitable for simultaneous multiple studies, in particular with the use of microtitration plates, and physical measurements of the results directly in the containers, for example of a microtitration plate. The multiple studies may be used to perform screening processes to discover and develop polymorphic and pseudorpolymorphic forms, new formulations and suitable crystallisation conditions.

Sealing system with flow channels

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Binningen, Switzerland

Brigitte Monika Cron-Eckhardt