Prometic Pharma Smt Limited

Prometic Biosciences Inc.

Liminal Biosciences Limited

Prometic Biotherapeutics, Inc.

Liminal R&d Biosciences Inc.

Brigitte Grouix

Lyne Gagnon

Boulos Zacharie

Pierre Laurin

Christopher L Penney

Shaun Abbott

Lilianne Geerts

Valérie Perron

Jean-François Bienvenu

François Sarra-Bournet

Martin Leduc

Jean-Francois Bienvenu

Jean-Simon Duceppe

Abdallah Ezzitouni

Nicole Wilb

Daniel Fortin

Alan D Cameron

Karine Houde

Nancie Moreau

Shaun D Abbott

The present invention concerns the use of plasminogen, a variant thereof, or an analog thereof having a plasminogen activity, for the prevention or treatment of a condition or a disease that is characterized with an increased PAI-1 level. The conditions and diseases that are characterized with an increased PAI-1 level, are regrouped within two categories: the diseases associated with an impaired vascular or tissue remodeling capacity, and the metabolic and hormonal disorders associated with an increased PAI-1 level.

Plasminogen treatment of conditions associated with PAI-1 overexpression

The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F or OH; Ris Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F, OH or CHPh; Ris H, F or OH; Q is

Substituted aromatic compounds and related method for the treatment of fibrosis

The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein

Substituted aromatic compounds for the treatment of pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis

The present invention concerns the use of compounds for preventing and/or treating osteoporosis, for stimulating bone formation, for stimulating bone remodeling, for stimulating the differentiation and mineralization of osteoblasts, for inhibiting bone resorption and for modulating serum level of adiponectin in a subject. These uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts thereof, wherein A is Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F or OH; Ris H, F, OH, Calkyl, Calkenyl, Calkenyl, C(O)(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F, OH or CHPh; Ris H, F, or OH; Q is 1) (CH)C(O)OH wherein m is 1 or 2, 2) CH(F)&#x2014;C(O)OH, 3) CF&#x2014;C(O)OH, or 4) C(O)&#x2014;C(O)OH.

Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis

The present invention concerns the use of compounds for preventing and/or treating osteoporosis, for stimulating bone formation, for stimulating the differentiation and mineralization of osteoblasts, or for inhibiting bone resorption in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts thereof. wherein: Rand Rare independently equal to H, F or OH; A is (CH)COOH, W(CH2)mCOOH, or Y&#x2014;CH(COOH)&#x2014;(CH2)p-CH3 when B is H; or B is (CH2)mCOOH, W(CH2)mCOOH, or Y&#x2014;CH(COOH)&#x2014;(CH)&#x2014;CHwhen A is H; or A and B are covalently bonded to form a five (5), six (6), or seven (7)-membered cycloalkyl substituted with COOH; where: Y is O, S, HN or CH; W is 0, S or NH; m is 0-2; and p is 3-7; D is CO(CH)CHor CHOH(CH)nCHor O(CH)CHwhere n is 2-6; and E is H or F.

Phenylketone carboxylate compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis

The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.

Substituted aromatic compounds and pharmaceutical uses thereof

The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, whereinA is Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4;Ris H, F or OH;Ris Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4;Ris H, F, OH or CHPh;Ris H, For OH;Q is

The present invention concerns the use of compounds for preventing and/or treating diabetes, for modulating glucose, insulin, and/or triglyceride levels; for reducing blood glucose level; for maintaining or increasing insulin level; for increasing insulin secretion; increasing insulin sensitivity; or decreasing insulin resistance in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts. wherein A is Calkyl, Calkyl, Calkenyl, Calkenyl, C(0)-(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F or OH; Ris Calkyl, Calkyl, Calkenyl, Calkenyl, C(0)-(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F, OH or CHPh; Ris H, F or OH; Q is 1) (CH)C(O)OH wherein m is 1 or 2, 2) CH(CH)C(O)OH, 3) C(CH)C(O)OH, 4) CH(F)&#x2014;C(O)OH, 5) CF&#x2014;C(O)OH, or 6) C(O)&#x2014;C(O)OH. 

Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of diabetes

The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F or OH; Ris Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, F, OH or CHPh; Ris H, F or OH; Q is 1) (CH)C(O)OH wherein m is 1 or 2, 2) CH(CH)C(O)OH, 3) C(CH)C(O)OH, 4) CH(F)&#x2014;C(O)OH, 5) CF&#x2014;C(O)OH, or 6) C(O)&#x2014;C(O)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.

The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is Calkyl, Calkyl, Calkenyl, Calkenyl, C(O)&#x2014;(CH)&#x2014;CHor CH(OH)&#x2014;(CH)&#x2014;CHwherein n is 3 or 4; Ris H, OH or F; Ris H, OH, F or CH&#x2014;OH; Ris H, OH, F or CHPh; Ris H, OH or F; Q is 1) (CH)C(O)OH wherein m is 1 or 2, 2) CH(CH)C(O)OH, 3) C(CH)C(O)OH, 4) CH(F)&#x2014;C(O)OH, 5) CF&#x2014;C(O)OH, or 6) C(O)&#x2014;C(O)OH. 

Substituted aromatic compounds for the treatment pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis

Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R&#x2550;C(0); &#x2014;OC(O)&#x2014; or &#x2014;CH(OH)&#x2014;; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction. 

Phenylketone carboxylate compounds and pharmaceutical uses thereof

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.

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Montreal, Canada

Brigitte Grouix