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Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur

Aventis Pharma S.a.

Brigitte Demers

Philippe J Sansonetti

Claude Parsot

Marie-Christine Bissery

Patricia Vrignaud

Marielle Chiron-Blondel

This invention relates to therapeutic combinations comprising VEGF Trap and a stilbene derivative, and to methods for treatment of cancer comprising administration of such combinations.

Combination comprising combretastatin and anticancer agents

This invention relates to mutant strains of gram-negative bacteria that constitutively secrete proteins via the type III secretion machinery and to methods of identifying molecules that are able to activate or inhibit secretion in wild-type strains of gram-negative bacteria by exposing gram-negative bacterial cells to a sample molecule, wherein the bacterial cells contain a reporter gene transcriptionally fused to a promoter of a gene activated or regulated by the type III secretion machinery and detecting the presence or activity of the product of the reporter gene.

Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria

This invention relates to mutant strains of gram-negative bacteria that constitutively secrete proteins via the type III secretion machinery. It also relates to methods of identifying molecules that are able to activate or inhibit secretion in wild-type strains of gram-negative bacteria by exposing gram-negative bacterial cells to a sample molecule, wherein said bacterial cells contain a reporter gene transcriptionally fused to a promoter of a gene activated or regulated by the type III secretion machinery, and detecting the presence or activity of the product of the reporter gene.

Method for screening for inhibitors and activators of type III secretion

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Paris, France

Brigitte Demers