Behringwerke Aktiengesellschaft

Brigitte Biesinger-Zwosta

Bernhard W Fleckenstein

Gerhard Jahn

Helmut Fickenscher

Ingrid Mueller-Fleckenstein

Sigrid Nick

The invention concerns the transformation of human T-lymphocytes to stable growth by infecting said T-cells with strains of H. saimiri subgroup NonA NonB, preferably subgroup C. The transformed cells grow independently of antigen stimulation and can have a phenotype of activated mature T-lymphocytes, expressing cell surface markers characteristic for the distinct differentiation status of the T-cells. Infection with strains of H. saimiri belonging to the subgroups above can thus be used to generate human T-cell lines for a variety of immunological and biochemical applications as well as for therapeutic use.

Stable growth transformation of human T-lymphocytes by Herpesvirus

A process is disclosed for replicating viruses of the HIV type which cause immune deficiency, in which process lymphocytes are employed which have been transformed with herpesvirus saimiri.

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Uttenreuth, Germany

Brigitte Biesinger-Zwosta