Nocion Therapeutics, Inc.

Flatley Discovery Lab, LLC

Axial Therapeutics, Inc.

Apm Therapeutics 1, Inc.

Retension Pharmaceuticals, Inc.

Bridget McCarthy Cole

James Lamond Ellis

Richard Allen Nugent

Yevgen Barsukov

Andrew Kolodziej

Michael Paul Zawistoski

Paul T Smith, Jr

Karen Handley

Alessandra Bartolozzi

Paul Sweetnam

Anthony Stewart Campbell

Jianmin Mao

Enoch Kim

Asmita Deshpande

Dhanapalan Nagarathnam

Richard A Nugent

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

Charged ion channel blockers and methods for use

The present invention provides solid, crystalline forms of Compound I. Compound I has the structure: The invention further provides methods for treating, preventing, or reducing a disease or disorder in a subject in need thereof, the methods comprising administering to the subject an effective amount of a crystalline form of Compound I. The disease or disorder may include any chronic disease and/or cardiovascular condition related to or caused by high blood pressure.

Crystalline forms of 4-ethoxy-n-(2-methoxyethyl)-n-methyl-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5, 1-f][1,2,4]triazin-2-yl)benzenesulfonamide

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are particularly useful for the treatment of itch and other dermal conditions.

The invention relates to a Form A polymorph of a triazolopyridine compound, pharmaceutical compositions and methods of use thereof.

Triazolopyridine polymorph A

Phosphonium ion channel blockers and methods for use

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:  The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

Ester substituted ion channel blockers and methods for use

The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.

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Quincy, MA, United States of America

Bridget McCarthy Cole