Eisai Inc.

Otsuka Pharmaceutical Company, Limited

Johns Hopkins University

Bridget Duvall

Dana Victor Ferraris

Gregory S Hamilton

Takashi Tsukamoto

Mark Vaal

Rena S Lapidus

Sergei Belyakov

Barbara S Slusher

Camilo Rojas

Niyada Hin

Sergel Belyakov

Gregory Hamilton

Dana Ferraris

Rena Lapidus

The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.

Certain compounds, compositions and methods

D-amino acid oxidase (DAAO) inhibitors and methods of their use, either alone or in combination with D-serine or D-alanine, to facilitate allosteric activation of NMDA receptor-mediated neurotransmission and methods of their use as therapeutic agents for treating a subject afflicted with one or more cognitive-disorders, such as schizophrenia, including subjects suffering from negative symptoms and cognitive impairments, post-traumatic stress disorder (PTSD), or pain, are disclosed.

Inhibitors of D-amino acid oxidase

Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.

Compositions and methods for treating cancer

Provided herein are methods of treating cancer comprising administering decitabine in combination with compounds that inhibit the deamination enzyme responsible for the inactivation of decitabine.

Growing community of inventors

Nottingham, MD, United States of America

Bridget Duvall