Massachusetts Institute of Technology

Abiomed, Inc.

The Brigham and Women's Hospital, Inc.

Other

X-cor Therapeutics Inc.

Tan, Qing

El Katerji, Ahmad

Brian Yale Chang

Elazer Reuven Edelman

Sonya Sanat Bhavsar

Noam Josephy

Ahmad El Katerji

Steven F Keller

Qing Tan

Alexander Ship

Christian Moyer

Steven Paul Keller

Jayon Wang

Noam Joesphy

Michael Alan Chang

Dong Chang

Steven Keller

Elazer R Edelman

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

Cardiovascular assist system that quantifies heart function and facilitates heart recovery

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

Systems, devices, and methods for extracorporeal removal of carbon dioxide

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Systems and methods for determining cardiac performance

The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Systems and methods for determining cardiac output

A golf club head that includes several slotted apertures that extend through the body of the club head, the slotted apertures being defined by several generally parallel, spaced-apart elongated spring members, the spring members can be used to create a lower stiffness at their mid-section rather than their ends.

Golf club head and inserts

Growing community of inventors

Cambridge, MA, United States of America

Brian Yale Chang