The Procter Gamble Company

Brian Wilson Howard

Duane Larry Charbonneau

Anthony Charles Lanzalaco

Raul Victorino Nunes

Freddy Arthur Barnabas

Robert Scott Youngquist

Nicholas William Geary

Jun Xu

Jose Carlos Garcia-Garcia

Yiping Sun

Robert Lloyd Binder

Safa Motlagh

Ping Hu

Teresa DiColandrea

Thomas Larry Dawson

Jeffrey Alan Henry

Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.

Systems and methods for identifying cosmetic agents for hair/scalp care compositions

The disclosure relates to topical compositions and methods comprising whole, non-viable Micrococcaceae cells, wherein the cells have been processed to kill the cells while minimizing lysis. The topical compositions and methods are useful for decreasing skin inflammation and improving skin barrier function.

Compositions and methods for improving skin health

A method for identifying test agents that exhibit prebiotic activity on human skin commensal microorganisms and compositions that include such agents. The method includes providing a test culture of a test agent, a human skin commensal microorganism and a minimal carbon medium. The method provides a time efficient and cost effective way to predict in vivo prebiotic activity of a test agent on skin commensal microorganisms.

Method of identifying prebiotics and compositions containing the same

A high-throughput, tiered screening method of indentifying test agents that exhibit prebiotic activity on human skin commensal microorganisms and cosmetic compositions that include such agents. The method includes determining the metabolite level of a culture and comparing the metabolite level to a control value. The assay further comprises performing a plate count using the culture when the metabolite level of the culture is greater than its corresponding control value. The plate count results are compared to another control value, and the test agent is identified as a prebiotic agent when the number of colonies present in the plate count assay of the culture is greater than the second control value.

A method for indentifying test agents that exhibit prebiotic activity on human skin commensal microorganisms and cosmetic compositions that include such agents. The method includes providing a test culture of a test agent, a human skin commensal microorganism and a minimal carbon medium. The method provides a time efficient and cost effective way to predict in vivo prebiotic activity of a test agent on skin commensal microorganisms.

Method of making cosmetic compositions containing a prebiotic

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Mason, OH, United States of America

Brian Wilson Howard