Eli Lilly and Company

Brian Weston Dalder

Wayne Douglas Luke

Kerry John Hartauer

Gordon Nelson Arbuthnot

Robert Eugene Stratford, Jr

Jeffrey Thomas Vicenzi

Samuel Dean Larsen

Sharon Van Den Berghe Snorek

Neil John Kallman

Michael Anthony Dotlich

Robert E Stratford

This invention provides compounds of formula I and pharmaceutically acceptable salts and solvates thereof, characterized that the compound is in particulate form and having a specific size range. The present invention further provides pharmaceutical compositions containing or formulated using compounds of formula I, and the use of such compounds for alleviating human pathologies, including osteoporosis, serum lipid lowering, and breast cancer.

Benzothiophenes, formulations containing same, and methods

This invention provides compounds of formula Iand pharmaceutically acceptable salts and solvates thereof, characterized that the compound is in particulate form and having a specific size range. The present invention further provides pharmaceutical compositions containing or formulated using compounds of formula I, and the use of such compounds for alleviating human pathologies, including osteoporosis, serum lipid lowering, and breast cancer.

A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nanofiltration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/metal salt to form a solubilized echinocandin nucleus salt having the desired anion, and subsequent cooling of the mixture to crystallize the salt.

Formation and anion-exchange of crystalline echinocandin ammonium salts

Benzothiophenes formulations containing same and methods

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West Lafayette, IN, United States of America

Brian Weston Dalder