Smithkline Beecham Corporation

Smithkline Beckman Corporation

Other

Brian W Metcalf

Dennis Alan Holt

Mark A Levy

James Francis Callahan

William F Huffman

William Edward Bondinell

Richard McCulloch Keenan

James Martin Samanen

Tobias Oregon Yellin

Jerry Leroy Adams

John G Gleason

Timothy Francis Gallagher

James S Frazee

Conrad John Kowalski

Ruth Judik Mayer

Ann Marie Tickner

Platelet aggregation inhibiting compounds

Cytokine inhibiting imidazole substituted hydroxamic acid derivatives

Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.

Steroid 5-alpha-reductase inhibitors

Invented are 3-acetic acid-steroidal compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase including using these compounds to reduce prostate size and to treat prostatic adenocarcinoma. Also invented are intermediates used in preparing these compounds.

Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors

Intermediates in the preparation of steriod 5-alpha-reductase inhibitors

Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase.

11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod

Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are methods for preparing these compounds.

7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha

The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase.

Phosphinic acid substituted steroids as inhibitors of steroid

New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.

Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of HMG-COA

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.

Steriod 5-alpha-reductase inhibitors

Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.

3-substituted nitro-steroid derivatives as 5-.alpha.-reductase inhibitors

Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.

Sulfonic acid substituted aromatic steroids as inhibitors of steroid

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.

Aromatic steroid 5-.alpha.-reductase inhibitors

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase. Also invented are intermediates used in preparing these compounds.

Growing community of inventors

Radnor, PA, United States of America

Brian W Metcalf