William Marsh Rice University

Dartmouth College

Brian Vincent Popp

Zachary Thomas Ball

Dean R Madden

Patrick R Cushing

Alexander Nikolaevich Zaykov

Rituparna Kundu

Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein.

Small molecule conjugates with dimetal species for protein inhibition

This application provides a metallopeptide catalyst comprising dirhodium bound to one or more carboxylate residues of a peptide, protein or peptidomimetic. These stable metallopeptides can achieve structure-selective protein modification though molecular recognition.

Metallopeptide catalysts

Growing community of inventors

Houston, TX, United States of America

Brian Vincent Popp