Leland Stanford Junior University

International Business Machines Corporation

University of California

Brian Trantow

Paul A Wender

James L Hedrick

Robert M Waymouth

Fredrik Nederberg

Bahram A Parvin

Joel M Hyman

Christina Barnes Cooley

Erika Geihe

Matthew Kiesewetter

The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular transporters (GR-MoTrs) for bringing molecular cargos into algal cells. The methods of the disclosure have been shown to work in wild-type algae that have an intact cell wall. Developed using, this method is also successful with less studied algae, includingand, thus providing a new and versatile tool for algal research and modification. The method of delivering a cargo compound to an algal cell comprises contacting an algal cell with a guanidinium-rich delivery vehicle comprising a guanidinium-rich molecular transporter (GR-MoTr) linked to a cargo compound desired to be delivered to the algal cell, whereby the guanidinium-rich molecular transporter can traverse the algal cell wall, thereby delivering the cargo compound to the algal cell.

Method for delivery of small molecules and proteins across the cell wall of algae using molecular transporters

A cyclic carbonate monomer, including:  The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.

Oligocarbonate molecular transporters

Growing community of inventors

Menlo Park, CA, United States of America

Brian Trantow