Chemapotheca, LLC

Albany Molecular Research, Inc.

Bone Care International, Inc.

Brian Thomas Gregg

Harold Meckler

Jie Yang

William Bert Geiss

Robert Jason Herr

William Earley

Mark A Helle

Richard G Pierce, Sr

The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.

Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof

The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.

Chiral aziridine phosphoramidate compounds

Chiral aryl or aryl-alkyl phosphoramidate dexamphetamine precursors having a regioisomeric purity &#x3e;99%

Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds

Synthesis of chiral amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds

An apparatus and method for simultaneously loading a plurality of small items such as small items into the wells of a multiple well microtiter plate which includes a small item loading unit and a small item insertion device. The small item loading device includes a top plate having a plurality of openings positioned to register with the microtiter plate wells and a closure unit to close the openings on one side of the top plate. The small item insertion device includes a base mounting a plurality of plunger pins which each register with a well in the microtiter plate. A movable deck unit is mounted in spaced relationship above the base and is provided with apertures, each of which receives a plunger pin. The small item loading device rests on the deck unit and the closure unit opens the openings therein to drop small items into the apertures over the pins. The deck unit is moved toward the base to cause the pins to enter the wells of a microtiter plate and seat the small items.

Multiple well microtiter plate loading assembly and method

The invention provides a method for making 24(S)-hydroxyvitamin D which is a stereospecific synthesis.

Method for making 24(S)-hydroxyvitamin D2

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Altamont, NY, United States of America

Brian Thomas Gregg