Active Motif, Inc.

Jelinek, Mary, Anne

Fernandez, Joseph

Egan, Brian, Stanley

Brian Stanley Egan

Mary Anne Jelinek

Joseph M Fernandez

Joseph Fernandez

Disclosed herein are compositions, methods and kits useful for epigenetic analysis based on the use of transposons that are targeted to specific regions of chromatin based on DNA-DNA interactions, protein-protein interactions, RNA-RNA interactions, and nucleic acid-protein interactions.

Targeted transposition for use in epigenetic studies

The invention provides novel methods and materials for genetic and genomic analysis using single or multiplex isolation of protein-associated nucleic acids, including transposase-assisted chromatin immunoprecipitation (TAM-ChIP) and antibody-oligonucleotide proximity ligation. These methods comprise tagging and isolating chromatin or other protein-associated nucleic acids and using antibody-oligonucleotide complexes that recognize the proteins associated with such nucleic acids.

Multiplex isolation of protein-associated nucleic acids

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Carlsbad, CA, United States of America

Brian Stanley Egan