Qualcomm Incorporated

University of California

The Salk Institute for Biological Studies

Qualcomm Innovation Center, Inc.

Qualcomm Connected Experiences, Inc.

Brian Spencer

Eliezer Masliah

Edward Rockenstein

Robert Marr

Haijun Zhao

Kenneth Scott Swinson

Inder M Verma

Wayne A Lee

Steven J Kinneberg

Todd J Johnsgard

In alternative embodiments, provided are compositions such as antibodies, e.g., single chain antibodies, that target 3-repeat (3R) Tau for the treatment of neurodegenerative disorders and taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation, and methods for making and using them. In alternative embodiments, provided are brain-penetrating antibodies that specifically recognize 3R Tau, and methods of using them to treat, ameliorate, prevent or decrease the symptoms of neurodegenerative disorders including taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation. Provided are methods for diagnosing a neurodegenerative disorder or a taupathy or any disorder or condition associated with a 3R Tau accumulation, and optionally the taupathy is Alzheimer's Disease, Pick's Disease or Fronto-temporal lobar degeneration.

Compositions targeting 3-repeat tau for the treatment of neurodegenerative disorders, and methods for making and using them

The disclosure is related to searching for a second device to provide a service that a first device is attempting to establish. The first device sends a search profile and a capabilities profile to the second device using near field communication (NFC), the search profile including criteria describing the service the first device is attempting to establish, the capabilities profile including connection capabilities of the first device, receives a score from the second device, the score indicating a closeness of a match between the search profile and the capabilities profile and one or more services and capabilities of the second device, and determines whether to connect with the second device to establish the service based on the received score.

System and method for enhance the user experience of applications for proximity-based peer-to-peer mobile computing

Methods and apparatuses for setting user preferences and/or device configuration information are disclosed. A first user device detects a local wireless network, receives, from a second user device, configuration information and/or preference information of the second user device, the second user device having functionality similar to the first user device, and updates configuration information and/or preference information of the first user device with at least a subset of the configuration information and/or preference information received from the second user device, the configuration information and/or preference information of the first user device stored at the first user device.

Method and apparatus for setting user preferences or device configuration

Methods and systems for the distributed bulk onboarding of devices onto a Wi-Fi network are provided. A method may comprise receiving, at an onboarding device, Wi-Fi configuration information. Then, it may comprise detecting, at the onboarding device, broadcast information from a plurality of devices that may be onboarded onto the Wi-Fi network, the broadcast information indicating that one or more of the plurality of devices is an onboarding node capable of onboarding another of the plurality of devices. The method may further comprise creating instructions indicating an order in which the plurality of devices may be onboarded, and by which of the one or more onboarding nodes each of the remaining devices of the plurality shall be onboarded, and providing the Wi-Fi configuration information and at least a portion of the instructions to at least one of the onboarding nodes.

Distributed bulk onboarding process

Apparatus and methods for collaboratively presenting content that is distributed among a plurality of communication devices are disclosed. The method includes providing a control service at a player device to enable communicatively coupled controller devices to control playback of media on the player device, and creating a single play queue at the player device that includes identifiers of media content selected by the controller devices. A stream of particular media content from one of the multiple source devices is received when the particular media content is identified at a top of the single play queue, the particular media content is rendered at the player device, and the rendered media content is presented to users associated with the controller devices.

Architecture for content awareness and control among peer-to-peer communication devices

The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation&#x2014;including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation. In one aspect, compositions and methods of this invention are used to treat, prevent or ameliorate (including slowing the progression of) Parkinson's disease, fronto-temporal dementia (FTD), Alzheimer's Disease (AD), Lewy body disease (LBD) and Multiple system atrophy (MSA).

Compounds for reversing and inhibiting protein aggregation, and methods for making and using them

This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs, lentiviral packaging systems, and lentiviral gene delivery systems. Finally, methods of transducing a cell and methods of targeting a gene to a cell or tissue using the disclosed lentiviral vectors and systems are also provided.

Growing community of inventors

San Diego, CA, United States of America

Brian Spencer