Biolife Solutions Incorporated

Biocision, LLC

Other

Cool Lab, LLC

Amgen Inc.

Astero Bio Corporation

Medcision, LLC

Azenta US, Inc.

Brian Schryver

Scott O Ganaja

Scott Comiso

Tark Abed

David Shannon

Rolf Erhardt

Wael Mismar

Ryan Braunstein

Kenneth Tan

Anthony Bantug

Mario Bogdan

Justin Allen Marsh

Jaime Brenner

Eric Kunkel

Thomas McPherson

Jeffrey E Schryver

Alex Dzigurski

Marc Mendoza

Systems and devices with enhanced stability to kinetic impact for the containment of cryogenically preserved material. A device comprising a vessel with increased surface to volume ratio when compared to cylindrical vessels of like capacity, and further comprising a material that remains resistant to shock and impact at cryogenic temperatures while providing a continuous barrier of a single material surrounding the vessel contents. The device further comprising a design that may be readily modified to include internalized sensors, enhanced interfacing to external instruments, provide optimized thaw rate, and post-thawing sample processing capabilities.

Multi-functional cryogenic storage vessel

A protective interface cushion device includes an upper half, a lower half, a cutout, a recessed surface, and an exclusion region. The upper half has a first interior surface and a first outer surface. The lower half has a second interior surface and a second outer surface. The first and second interior surfaces are configured to receive a cryostorage bag. The cutout forms an opening through at least one of the first interior surface, the first outer surface, the second interior surface, and the second outer surface. The cutout is configured to restrict a first cryostorage bag fill volume. The recessed surface, on the first and/or second interior surfaces, is configured to restrict a second cryostorage bag fill volume. The exclusion region, between the first interior surface and the second interior surface, is configured to displace liquid contents of the cryostorage bag into the first and/or second fill volume.

Systems and methods for cryostorage bag protection

Systems, devices and methods for shaping a liquid material within a cryostorage bag while undergoing a freezing procedure.

Shaping liquid material in a cryostorage bag to obtain desired solid shape

A system and method for concurrently and uniformly removing thermal energy from a specimen sample. A thermal insulating device is provided comprising an insulating material, the device having a plurality of chambers for receiving specimen samples, the device further includes a thermal ballast whereby the rate of thermal energy removal is controlled and influenced by the thermal ballast.

Specimen freezing rate regulator device

A consistent and repeatable thawing method of frozen samples in a bag-format storage vessel is described herein. Methods and systems may allow for multiple bag-format storage vessel sizes to be used in the same device. A subset of a plurality of sensors may be qualified for the thawing method. The method may further include heating a frozen sample using a first heater bank and a second heater bank. In addition, the method may include measuring a plurality of second temperatures of the bag-format vessel. At or slightly after a second threshold temperature, the method may include heating using the first heater bank and terminating heating using the second heater bank. The method may include terminating the heating of the partially thawed sample using the first heater bank after the partially thawed sample has been heated using the first heater bank for a duration.

Cryobag thawing methods

Cryogenic devices are provided in which solid carbon dioxide (dry ice) is used to maintain a temperature zone in which samples can be manipulated under conditions in which the sample is maintained at a temperature below &#x2212;50&#xb0; C.

Cryogenic systems

A sleeve for securing a cryogenic vial includes a cylindrical body sized to receive a vial, the body including a longitudinal axis, a first end, and a second end. A plurality of deformable members are disposed near the first end of the body and are arranged to deform from a first configuration to a second configuration. Each deformable member is displaced outwardly relative to the longitudinal axis of the body in the second configuration.

Vial sleeve assembly

The present invention generally relates to thawing a cryogenically frozen sample. The systems, devices, and methods may be used to heat a sample holder, the sample holder configured to receive a sample container holding the frozen sample. A sample thaw start time may be identified by measuring a temperature of the sample container and/or a temperature of the sample. A sample thaw end time may be calculated as a function of the sample thaw start time. In some embodiments, the same thaw start time may be identified by a significant change in a first derivative of a warming curve of recorded temperature measurements. The sample end time may be calculated by adding a constant to the sample thaw start time. The constant may be the average sample thaw time per the sample container.

Systems, devices, and methods for automated sample thawing

The present disclosure is related to sample thawing. Features described herein may limit power requirements of the thawing device and may thereby increase the portability of the thawing device. The device may include a housing; a heater block housed within the housing and forming a vial receptacle; a thermally-conductive compliant material may line an inner surface of the receptacle; and a heating element may be coupled with the heater block. The thermally-conductive compliant material may be molded to a shape of a bottom portion of the vial so as to fittingly mate with the bottom portion of the vial. In some embodiments, the heater block does not have moveable components and may be a single non-segmented piece. An ejection pin may be provided configured to break contact between the vial and the thermally-conductive compliant material. Additionally, the receptacle may be localized to the vial region adjacent to the frozen sample.

Portable thawer components and features

A portable heat transfer device for transferring thermal energy to and/or from laboratory tubes, clinical vials, specimen vials, laboratory vials, serum vials, drug vials and laboratory containers is provided. The heat transfer device comprises an insulated, thermally conductive heat conduit system and base for the purpose of exchanging heat between the laboratory container and a thermoregulatory device.

Thermal energy transfer device

Cryogenic devices are provided in which liquid nitrogen is used to maintain ultra-low temperatures in which samples can be manipulated.

Cryogenic workstation using nitrogen

Cryogenic devices are provided in which solid carbon dioxide (dry ice) is used to maintain a temperature zone in which samples can be manipulated under conditions in which the sample is maintained at a temperature below &#x2212;50 C.

Growing community of inventors

Redwood City, CA, United States of America

Brian Schryver