Ut-battelle, Inc.

Brian Sanders

Jerry M Parks

Stephanie S Galanie

A compound having the following structure: wherein: Ris a linker having the formula —(CH)-L-, wherein Lcontains 1-6 carbon atoms and at least one —NH— linkage and at least one oxygen-containing or sulfur-containing linkage, and n is an integer of 0-3; Ris a group having the formula —C(Y)-E, wherein Y is O or S, and E is a hydrocarbon group and either: (i) at least one carbon-carbon or carbon-nitrogen unsaturated bond or (ii) at least one alkyl halide group; Ris selected from H, NR', NHC(O)R′, and —(CH)-T, wherein T contains at least one —NH— linkage; R, R, R, R, R, and Rare independently selected from of H, hydrocarbon groups containing 1-3 carbon atoms, fluorine atom, and chlorine atom; X is N or CR, wherein Ris selected from H, hydrocarbon groups containing 1-3 carbon atoms, fluorine atom, and chlorine atom; and pharmaceutically acceptable salts thereof.

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Knoxville, TN, United States of America

Brian Sanders