Princeton University

The State University of New York

Other

Brian Saam

William Happer

Gordon D Cates, Jr

Bastiaan Driehuys

Dilip Balamore

Mitchell S Albert

Arnold Wishnia

Eli Miron

Daniel K Walter

Hunter Middleton

A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.

Magnetic resonance imaging using hyperpolarized noble gases

Magnetic resonance imaging using Hyperpolarized noble gases

A method and apparatus for accumulation of hyperpolarized .sup.129 Xe is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized .sup.129 Xe in frozen form. The method also permits the accumulation of hyperpolarized .sup.129 Xe to the substantial exclusion of other gases, thereby enabling the purification of hyperpolarized .sup.129 Xe. The invention further includes .sup.129 Xe accumulation means which is integrated with .sup.129 Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized .sup.129 Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

Cryogenic accumulator for spin-polarized xenon-129

A method and apparatus for accumulation of hyperpolarized .sup.129 Xe is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized .sup.129 Xe in frozen form. The method also permits the accumulation of hyperpolarized .sup.129 Xe to the substantial exclusion of other gases, thereby enabling the purification of hyperpolarized .sup.129 Xe. The invention further includes .sup.129 Xe accumulation means which is integrated with .sup.129 Xe hyper polarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized .sup.129 Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

A method and apparatus for hyperpolarization of flowing noble gases is disclosed, including means for hyperpolarization of noble gases in a continuous flow arrangement. Noble gases such as xenon-129 and helium-3 can be hyperpolarized using the disclosed method and apparatus. Preferably, the noble gas is hyperpolarized via spin exchange between atoms of the noble gas and an alkali metal such as rubidium. Also, a method and apparatus for accumulation and/or storage of hyperpolarized noble gases in a continuous flow arrangement is provided. The method and apparatus enable large scale production, storage, and usage of hyperpolarized noble gases for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

High volume hyperpolarizer for spin-polarized noble gas

Growing community of inventors

Princeton, NJ, United States of America

Brian Saam