Aroa Biosurgery Limited

Mesynthes Ltd.

Brian Roderick Ward

Keryn Dallas Johnson

Barnaby Charles Hough May

Andrew Raymond Campbell

Barnaby Charles May

A tissue graft product comprising two or more layers of material wherein each layer comprises extracellular matrix (ECM) or polymeric material and wherein the layers are laminated together by interlocking portions of one layer with portions of another layer.

Laminated tissue graft product

A tissue graft comprising two or more layers of material wherein each layer comprises extracellular matrix (ECM) or polymeric material and wherein the layers are laminated together by interlocking portions of one layer with portions of another layer. In one embodiment, a tissue graft comprises a first layer of material having multiple lugs and a second layer of material having multiple holes, each lug of the first layer being located through a hole in the second layer, the holes and the lugs having dimensions so that the lugs engage with a surface of the second layer and interlock the first layer with the second layer. In further embodiments, a method of preparing a tissue graft by laminating and interlocking two or more layers, the use of a tissue graft for replacing or repairing tissue in a human or animal, and an apparatus comprising a mould, a lug cutting means, a piercing means and a means for pushing lugs through piercings in layers of a tissue graft.

The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.

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Wellington, New Zealand

Brian Roderick Ward