Other

Dow Agrosciences LLC

Dowelanco

Brian R Thoreen

Gary D Crouse

Thomas Clarence Sparks

Carl Vincent DeAmicis

Peter Lee Johnson

Herbert A Kirst

James Michael Gifford

Barry A Dreikorn

Vidyadhar Babu Hegde

Lawrence C Creemer

Robert G Suhr

Peter Biagio Anzeveno

Neil Vincent Kirby

Glen P Jourdan

Michael John Ricks

Ronald E Hackler

Joe Raymond Schoonover

Frederick Richard Green, Iii

Thomas V Worden

Sylvester V Kaster

Christopher J Hatton

Jack G Samaritoni

Kevin L McLaren

Jacek G Martynow

The compounds of the present invention are prepared directly or indirectly by modifying the compounds that are naturally produced from Saccharopolyspora spinosa. The compounds of the invention have been shown to have activity against insects and mites. The compounds are prepared by modifying the rhamnose sugar, modification of the forosamine sugar, or starting with pseuodoaglycone and then replacement with a nonsugar derivative or different sugar, modification of the 5,6,5-tricyclic and 12-membered macrocyclic lactone part of the compounds naturally produced or of the pseudoaglycone of the natural compounds.

Synthetic modification of Spinosyn compounds

N-(4-Pyridyl or 4-quinolinyl) arylacetamides, for example N-((3-chloro-2-ethyl)-4-pyridyl)(4-(4-chlorophenoxy) phenyl)-acetamide, and 4-(aralkyoxy or aralkylamino)pyridines, for example 4-[2-[4-(2,2,2-trifluoroethoxy)phenyl]ethoxy]pyridine, are active against nematodes, insects, mites, and plant pathogens.

N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or

Compounds of the formula (I): ##STR1## wherein: Het is pyridyl, pyrazinyl, pyrimidinyl, or pyridizinyl, optionally substituted with one or more groups selected from halo, lower alkyl, lower alkoxy, haloalkyl, haloalkoxy, NO.sub.2, CN, and lower alkoxy-carbonyl;

4-(2-(4-(2-pyridinyloxy)phenyl)ethoxy)quinazoline and analogues thereof

Growing community of inventors

Indianapolis, IN, United States of America

Brian R Thoreen