University of Pennsylvania

The University of British Columbia

Battelle Memorial Institute

Fpinnovations

Brian R James

William R Dolbier, Jr

An-Rong Li

Cameron J Koch

Kirsten A Skov

Alexander V Kachur

Chyng-Yann Shiue

Sydney M Evans

Ian R Baird

Michael A Lilga

James P Kutney

Thomas Hu

David A Nelson

Michael D Fryzuk

Dominggus Yawalata

Guo-Jun Kang

Roberto Spogliarich

Maria B Ezhova

Ian S Thorburn

Chung Li-Lee

William R Cullen

A method for the bleaching and brightness stabilization of lignocellulosic materials is described. The method involves the treatment of lignocellulosic materials, in particular, (a) wood pulps such as thermomechanical pulps (TMP) and chemithermomechanical pulps (CTMP), and (b) papers made from wood pulps, with a water-soluble phosphine or a phosphonium compound preferably containing at least one phosphorus hydroxyalkyl bond/linkage, for example a phosphorus hydroxymethyl bond/linkage (P&#x2014;CHOH). One example of such a water-soluble phosphine is the commercially available, tris(hydroxymethyl)phosphine (THP), P(CHOH). One example of such a phosphonium compound is the commercially available, tetrakis(hydroxymethyl)phosphonium chloride (THPC), [P(CHOH)]Cl.

Bleaching and brightness stabilization of lignocellulosic materials with water-soluble phosphines or phosphonium compounds

Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Detection of hypoxia

Nitroaromatic compounds for the detection of hypoxia

Asymmetric hydrogenation of prochiral N-arylketimines to give optically active secondary amines at a temperature from -40.degree. to 80.degree. C., under a hydrogen pressure of 10.sup.6 to 10.sup.8 Pa and with the addition of catalytic amounts of a rhodium compound of the formula III or IIIa ##STR1## in which X is 2 olefin ligands or a diene ligand, Y is a chiral diphosphine in which the secondary phosphine groups are linked by 2-4 C atoms and which, together with the Rh atom, forms a 5-membered, 6-membered or 7-membered ring, or Y is a chiral disphosphinite in which the phosphinite groups are linked via 2 C atoms and which, together with the Rh atom, forms a 7-membered ring, Z is Cl, Br or I and A.sup.- is the anion of an oxygen acid or complex acid.

Process for the preparation of optically active secondary arylamines

A process of abstracting sulfur from H.sub.2 S and generating hydrogen is disclosed comprising dissolving Pd.sub.2 X.sub.2 (.mu.-dppm).sub.2 in a solvent and then introducing H.sub.2 S. The palladium complex abstracts sulfur, forming hydrogen and a (.mu.-S) complex. The (.mu.-S) complex is readily oxidizable to a (.mu.-SO.sub.2) adduct which spontaneously loses SO.sub.2 and regenerates the palladium complex.

Process for recovery of hydrogen and abstraction of sulfur

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Brian R James