Triple Ring Technologies, Inc.

Vioptix, Inc.

Empyrean Medical Systems, Inc.

Covidien LP

Leland Stanford Junior University

Han Sen Medical, Inc.

Alara, Inc.

Novaray Medical, Inc.

Nellcor Puritan Bennett Incorporated

Restoration Robotics, Inc.

Sensus Healthcare, Inc.

Nextray, Inc.

Eklin Medical Systems, Inc.

Ocela Technologies, Inc.

Brian Patrick Wilfley

Joseph A Heanue

Tobias Funk

Kate LeeAnn Bechtel

Edward Gerald Solomon

Donald J Olgado

Chwen-Yuan Ku

Kalman Fishman

Petre Vatahov

Waldo Stephen Hinshaw

Christopher R Mitchell

Augustus Percival Lowell

Christopher W Ellenor

Steve Burion

Norbert Joseph Pelc

John F Heanue

Josh Star-Lack

Lester John Lloyd

H Keith Nishihara

Stuart L Friedman

Thomas Anthony Case

Eric J Shrader

Sung Hoon Kim

Mohan Bodduluri

Perry Q Anderson

Rebecca Fahrig

William Friederich Witt

Peter Holst

Zhong Zhong

Etta Pisano

Douglas A Reim

Gary Cantu

Christopher A Parham

Dean Connor

Wayne Evans

Yonatan Vainer

James Olef Jensen

Heather Klaubert

Kate L Bechtel

Gary R Cantu

Ron Smith

Joseph Anthony Heanue

Steve Denis Burion

Augustus Percivall Lowell

Systems and methods for generating X-ray photons. The methods comprise: generating an electron beam; positioning hollow pedestals in the path of the electron beam (the hollow pedestals being radially spaced apart from each other and extending out and away from a major planar face of a base plate); generating X-ray radiation as a result of an interaction of the electron beam with target element(s) disposed at a distal end of a respective pedestal of the hollow pedestals; causing the X-ray radiation to interact with a beam shield comprising wall elements extending out and away from the major planar face of the base plate; and setting at least one of a beam shape and direction of the X-ray radiation by selectively controlling a location where the electron beam intersects the target element(s) to determine an interaction of the X-ray radiation with the wall elements.

Three-dimensional beam forming X-ray source

X-ray target element is comprised of a planar wafer. The planar wafer element includes a target layer and a substrate layer. The target layer is comprised of an element having a relatively high atomic number and the substrate layer is comprised of diamond. The substrate layer is configured to support the target layer and facilitate transfer of thermal energy away from the target layer.

A sensor head for a compact oximeter sensor device includes light sources and light detectors. A compact oximeter sensor device implementation is entirely self-contained, without any need to connect, via wires or wirelessly, to a separate system unit. The sources and detectors are arranged in a circular arrangement having various source-detector pair distances that allow for robust calibration and self-correction in a compact probe. Other source-detector arrangements are also possible.

Tissue oximetry probe geometry for robust calibration and self-correction

Validation of a therapeutic radiation treatment involves using an applicator balloon surrounding an X-ray radiation source to support a plurality of X-ray sensor elements (XRSE). The XRSE are supported on the applicator balloon at distributed locations to sense applied radiation from the radiation source. At least one parameter of the applied radiation which has been sensed by the XRSE is compared to a corresponding parameter of a predetermined radiation treatment plan. Based on the comparing, a determination is made as to whether one or more requirements of the predetermined radiation treatment plan have been satisfied.

Validation of therapeutic radiation treatment

A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a light source into a tissue phantom, detecting in a plurality of detectors the light emitted from the light source, subsequent to reflection from the tissue phantom, and generating a set of detector responses by the plurality of detectors based on detecting the light emitted from the light source. The method further includes determining a set of differences between the set of detector responses and a reflectance curve for the tissue phantom, and generating a set of calibration functions based on the set of differences. Each calibration function in the set of calibration functions is associated with a unique, light source-detector pair. The method further includes storing the set of calibration function in a memory of the self-contained, tissue oximetry device.

Robust calibration and self-correction for tissue oximetry probe

Three-dimensional beam forming x-ray source

Three dimensional beam forming X-ray source includes an electron beam generator (EBG) to generate an electron beam. A target element is disposed a predetermined distance from the EBG and positioned to intercept the electron beam. The target element is responsive to the electron beam to generate X-ray radiation. A beam former is disposed proximate to the target element and comprised of a material which interacts with the X-ray radiation to form an X-ray beam. An EBG control system controls at least one of a beam pattern and a direction of the X-ray beam by selectively varying a location where the electron beam intersects the target element to control an interaction of the X-ray radiation with the beam-former.

The present invention pertains to a method and an apparatus for Raman spectroscopy of human tissue. Human tissue is illuminated with a laser emitting a first wavelength of light. A Raman signal is measured and optical properties are determined at this wavelength such that the measured Raman signal can be corrected based on determined optical properties. Determined optical properties may be the scattering coefficient and absorption coefficient of the tissue. A system for Raman spectroscopy of human tissue includes a frequency sweeping laser light source for illumination, and a filtered detector for collecting the Raman signal.

Intrinsic and swept-source raman spectroscopy

The present invention pertains to an apparatus for generating a charged particle beam comprising a magnetic element for controlling the profile of the beam in a predetermined plane. A cathode can be provided for emitting charged particles and an anode for accelerating the charged particles along an axis of travel. The present invention also pertains to a method for generating a particle beam that has a uniform profile in a predetermined plane comprising inducing emission of charged particles from an emitter, accelerating those particles along and toward an axis of beam travel, generating a magnetic field with a component aligned with the axis of beam travel but different in the predetermined plane than at the emitter, and modifying the beam profile.

Method and apparatus for generation of a uniform-profile particle beam

The present invention pertains to an apparatus and method for adaptive exposure in imaging systems. An x-ray source for producing x-ray radiation and an x-ray detector for measuring amount of x-ray radiation passing through the human patient and striking the detector can be used. A tomographic image of the human patient or a tomosynthetic image of the human patient can be generated. Region of interest filtering and equalization filtering can be utilized. Filtering can be accomplished with a mechanical shield or shutter or with electronic control of the x-ray source.

Method and apparatus for controlling X-ray exposure

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Sunnyvale, CA, United States of America

Brian Patrick Wilfley