Vanda Pharmaceuticals Inc.

Brian Patrick Hennessy

Andrea Vaclavkova

Michel Burcklen

Hilke Kracker

Sivi Ouwerkerk-Mahadevan

Tatiana Sidorenko

Allitia DiBernardo

Tarek El Akkad

Alexander Keenan

The disclosure relates to methods of treating multiple sclerosis using Ponesimod. In certain aspects, these include methods of avoiding worsening of fatigue-related symptoms in a human patient who has had no prior disease modifying treatment (DMT) for multiple sclerosis, who has a baseline expanded disability status scale (EDSS) score of ≤3.5, or who does not have Gd+/T1 lesions at baseline.

Ponesimod for avoiding worsening of fatigue-related symptoms in multiple sclerosis patients

The disclosure relates to methods of treating multiple sclerosis. Also provided are pharmaceutical products containing ponesimod, instructions for use of ponesimod, methods for selling a drug product containing ponesimod, and methods for reducing clinical management events before or during treatment of multiple sclerosis.

Methods of treating multiple sclerosis

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Geneva, Switzerland

Brian Patrick Hennessy