University of California

Ionis Pharmaceuticals, Inc.

Brian Parks

Richard Theodore Lee

Aldons J Lusis

Provided herein are methods, compounds, and compositions for reducing expression of an AGPAT5 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids, insulin resistance and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cardiometabolic disease, disorder or condition, or a physiological marker thereof, in an individual in need.

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Los Angeles, CA, United States of America

Brian Parks