Lawrence Livermore National Security, LLC

Other

Brian P Mayer

Carlos A Valdez

Edmond Y Lau

Daniel Joseph Kennedy

Roald N Leif

Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals. Advantageously, the catalytic homopiperazine-based ligand-metal complexes are formed using inexpensive, readily-available precursor materials, and may be utilized to neutralize toxins without relying on damaging caustic reactants or environmentally unfriendly organic solvents.

Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds

Novel thioalkylcarboxylate-modified CDs and pharmaceutical compositions comprising these thioalkylcarboxylate-modified CDs are disclosed, as well as methods of using the disclosed thioalkylcarboxylate-modified CDs and pharmaceutical compositions thereof to neutralize or reduce undesired effects or symptoms associated with one or more fentanyl related compounds in a subject in need thereof. The use of the disclosed thioalkylcarboxylate-modified CDs to detect the presence of one or more fentanyl related compounds in a sample is also disclosed, which comprises contacting the sample with said thioalkylcarboxylate-modified CDs or a composition comprising these CDs.

Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof

A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.

Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same

In one embodiment, a method includes contacting a phosphotriester and a halogen salt in a polar solvent. In another embodiment, a method for dealkylating tributylphosphate includes contacting tributylphosphate and a halogen salt in a polar solvent.

Halide-mediated dealkylation of phosphotriesters

Fastener

The present invention is generally directed to a swim fin generally including a fin blade and a bootie, the bootie including a foot pocket configured to receive a user's foot and ankle, the foot pocket attached to the top surface of the fin blade; and a strap system including one or more straps pulling the user's foot and ankle into the foot pocket toward the distal edge of the fin blade and down against a top surface of the fin blade. Some aspects of the present invention may also include a foot pocket formed from a first portion having a first elastic characteristic connected to the top surface of the fin blade; and a second portion having a second elastic characteristic portion disposed at least on a portion of the top surface of the foot pocket, the second elastic characteristic being greater than the first elastic characteristic.

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San Francisco, CA, United States of America

Brian P Mayer