Novo Nordisk A/s

Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Brian Mouridsen

Bennie Peder Smiszek Pedersen

Jesper Hoeholt

Bastian Gaardsvig Kjeldsen

Lars Morten Bom

Robert Samuel Langer

Carlo Giovanni Traverso

Morten Revsgaard Frederiksen

Brian Jensen

Jorrit Jeroen Water

Steffen Hansen

Alex G Abramson

Jesper Peter Windum

Niclas Roxhed

Jim Radmer

Simon Roervig

Simon Munch Pedersen

Laurits Hoejgaard Olesen

Jacob Wainer

Steven Linnebjerg

Mikkel Oliver Jespersen

Andreas Vegge

Yi Lu

Mette Poulsen

Kim Ejholm Hansen

Drago Sticker

Declan Gwynne

Adam Bohr

Kim Frandsen

Bozhidar Nikolaev Kozhuharov

Jacob Pyung Hwa Jepsen

Aghiad Ghazal

Cody Cleveland

Siheng You

Graham Arrick

Torben Sebastian Last

Xiaoya Lu

Mikkel Wennemoes Hvitfeld Ley

Jesper HØHOLT

Simon RØRVIG

A drug delivery assembly comprising a magnetic indicator and a sensor system is provided. The indicator is arranged to rotate and move axially relative to a housing component and corresponding to a reference axis, the amount of rotation being indicative of the size of an expelled dose amount. The sensor system comprises a sensor component adapted to measure a property of the indicator indicative of a rotational position and/or a rotational movement of the indicator. The sensor component forms part of release assembly adapted to be moved into engagement with a release member to release a set dose, and subsequently to move axially together with indicator.

Drug delivery assembly with moving sensor system

A medical delivery device suitable for insertion into a lumen of a patient, the medical device () comprising a capsule () sized to be inserted into the lumen, the capsule comprising a base member, and an actuation mechanism comprising an actuation member () configured for movement relative to the base member along an axis, and an energy source () associated with the actuation member for powering the actuation member to move relative to the base member along the axis. The base member and the actuation member define a latch assembly comprising: a) a dissolvable firing member (), the dissolvable firing member being at least partially dissolvable when subjected to a biological fluid, b) a retainer portion () comprised by one of the base member and the actuation member, and c) a movable latch () configured for lateral movement relative to the axis, the movable latch defining a first surface with a blocking portion (), and a second surface () configured for interacting with the dissolvable firing member (). In a pre-firing configuration, the blocking portion () of the movable latch engages the retainer portion () in a latching engagement, and the second surface () of the movable latch interacts with the dissolvable firing member to restrict lateral movement of the movable latch thereby preventing release of the latching engagement. In a firing configuration where the dissolvable firing member () has become at least partially dissolved, the movable latch is allowed to move laterally thereby releasing the latching engagement.

Medical device with actuation mechanism

A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.

Drug delivery device

An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner sensor assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of providing a stable inner platform for the sensor means, which in accordance with the invention is realized by actuating a clutch between the pen housing and the pen dose setting member during dose sensing, this preventing to a high degree that the inner sensor assembly rotates relative to the drug delivery housing during actuation of the drug expelling means.

Accessory device for drug delivery device

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

Systems and methods for liquid injection

An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of preventing transfer of movement from the add-on dose setting member to the inner assembly during dose expelling, which in accordance with the invention is realized by rotationally de-coupling the inner and outer assembly during dose expelling.

The present invention relates to an injection device () for setting and injecting set doses from a held drug cartridge (). The injection device () comprises a housing (), a piston rod (), a rotatable driver () and a dose setting device (). The dose setting device () comprises a predetermined stop to limit the amount of an expelled dose corresponding to the amount of a set dose. A secondary stop limiter includes first () and second () components and a secondary stop track follower () arranged between the first () and second () components. If the predetermined stop fails to stop the driver () at the end of injection, the secondary stop track follower () moves towards a safety stop () to prevent the driver () from rotating further.

Medical injection device comprising a secondary safety limiter

The present invention relates to an injection device () for setting and injecting set doses from a held drug cartridge (). The injection device () comprises a housing (), a piston rod (), a rotatable driver () and a dose control member (). A stored energy source () is configured to drive rotation of the driver () to cause the piston rod () to expel a set dose. The dose control member () rotates during dose setting and during dose expelling. A first clutch (C) is arranged between the dose control member () and the driver (). A second clutch (C) is arranged between the driver () and the housing () to control the expelling movement. During dose setting the first clutch (C) is disengaged and the second clutch (C) is engaged. During dose expelling the first clutch (C) is engaged and the second clutch (C) is disengaged.

Medical injection device

The present invention relates to a medical injection system comprising a medical injection device () of the type comprising a rotatable dose setting member (). The system further comprises a dose limiter module () adapted for being releasably coupled to the injection device (). The dose limiter module () comprises a dose limiter base () and a limiter () arranged relative to the dose limiter base () so that their relative position is adjustable to set an adjusted dose limiting position. When the dose limiter module () is coupled to the injection device (), the limiter () cooperates with the dose setting member () to define a blocking means for preventing rotation of the dose setting member () beyond the adjusted dose limiting position. The dose limiter module () further comprises a user operable lock () configured for operation between a locked state and an unlocked state to respectively prevent and enable modification of the adjusted dose limiting position, the lock () being configured for maintaining the lock in the locked state at least when the dose limiter module () is not coupled with the injection device ().

Medical injection system comprising a medical injection device and a dose limiter module

The present invention relates to an injection device for automatic torsion spring driven injection of a liquid drug. The injection device is of the type wherein a telescopically movable needle shield () activates the release of the torque of the torsion spring to drive the injection when the needle shield is moved from its extended position to a retracted position. The injection device is provided with a needle interface () carrying the injection needle, which needle interface is provided with means () preventing axial movement of the shield when no injection needle is mounted. Further, other means are provided to restrain the needle shield in the retracted position when the injection device is its 'zero' position such that a user has access to the injection needle in order to exchange the injection needle.

Shield lock for spring driven injection device

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Fredensborg, Denmark

Brian Mouridsen