Qualcomm Incorporated

Biogen Idec Ma Inc.

Pfizer Corporation

Sanford Burnham Prebys Medical Discovery Institute

Biogen Ma Inc.

Snaptrack Incorporated

Brian Miller

Adam Edward Newham

Rohit Sauhta

Jose Roberto Menendez

Scott Glaser

Alexey Alexandrovich Lugovskoy

Stephen John Demarest

Xiufeng Wu

William Brian Snyder

Lisa Croner

Tigran Aivazian

Norman Wang

Joel Linsky

Carl F Ware

John Sedy

Natasha K Crellin

Justin Andrew Caravella

Kevin Wayne Bartig

Susan Foley

Raymond Alexander Moy

Xiaoping Hronowski

The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

BTLA fusion protein agonists and uses thereof

A system for receiving multiple conversations or messages and for playing the multiple conversations or messages with a mobile device and wireless earpieces. The system may determine various presentation parameters based on various characteristics of the received messages and may play the messages such that audio appears at distinguishing locations around the user. The system may change how messages and/or conversations are played in response to recognize a change in the focus of the user based on detected user inputs, such as body movement gestures.

Audio systems and methods

Embodiments include systems and methods of allocating application functions to motion-correlated devices. A processor may determine whether a first motion of a first mobile device and a second motion of a second mobile device are correlated. The processor may allocate a first application function to the first mobile device and a second application function to the second mobile device in response to determining that the first motion and the second motion are correlated.

Methods and systems of allocating application functions to motion-correlated devices

Embodiments include systems and methods of verifying wireless devices for paring without user interaction or with reduced user interaction. A processor may send, from a first wireless device to a second wireless device, a discovery query, and may receive a discovery response from the second wireless device. The processor may authenticate, in the first wireless device, the second wireless device based on the discovery response. The processor may send, from the first wireless device to a second wireless device, a first capability query. The processor may receive, in the first wireless device from the second wireless device, a first capability response including first capability response information. The processor may authenticate, in the first wireless device, the second wireless device based on the first capability response information. The processor may initiate a pairing process between the first and second wireless devices when the first wireless device authenticates the second wireless device.

Methods and systems of pairing wireless devices

The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of posttranslational modifications to the polypeptides which comprise them. More specifically, the novel linker peptides disclosed herein reduce the ability of enzymes to link carbohydrate adducts to polypeptides comprising these linker peptides, e.g., reduce the ability of xylosyltransferase to link xylose to polypeptides. These novel linker peptides, molecules comprising same, and methods of their use are described.

Linker peptides and polypeptides comprising same

Systems and methods for managing concurrent audio messages

Methods, devices, and systems for transmitting convenient messages to a recipient for rendering based on the recipient's device availabilities. A recipient's mobile device may be connected to a personal hub and/or earpiece devices configured to render various incoming communications, such as audio messages and visual messages. The incoming messages may be delivered to the recipient's mobile device and other connected devices that may render the contents of the incoming messages. A delivery confirmation message that describes the receipt and use of incoming messages may be generated and returned to a sender's computing device. In an embodiment, the recipient's devices may generate status information for describing the status of devices to a sender's computing device. In an embodiment, the sender's computing device may generate and transmit outgoing messages formatted based on the received status information and including metadata that instructs the recipient's devices to render message content in particular manners.

Personal hub presence and response

The systems, methods, and devices of the various embodiments provide call control information from a mobile phone to another device by moving the functionality enabling the separation of call control commands from audio data off the mobile phone. The various embodiments handle the separation of call control commands from audio data at an ear piece or other peripheral device, such as a personal hub, which is part of a multiple subscriber device system. The various embodiments enable the standard Bluetooth&#xae; Hands-Free Profile to be used by a multiple subscriber device system to interact with a mobile phone.

Method of providing call control information from a mobile phone to a peripheral device

Systems, methods, and devices synchronize data streams by hashing received data frames to generate a sequence of hash values, comparing the generated hash value sequence to a hash value sequence received in a control stream, and processing data frames when the hash value sequences match. A source device and multiple receiver devices may synchronize audio data encoded in data frames, applying a hash function to each data frame to generate a first sequence of hash values, transmitting the data frames on a first channel and the first sequence of hash values on a control channel, receiving the data frames and the first sequence of hash values in the receiver devices, applying the hash algorithm to received data frames to generate a second sequence of hash values, comparing the first and second sequences of hash values, and processing data frames when the first and second sequences of hash values match.

Frame sync across multiple channels

An apparatus for extending Bluetooth device range includes a Bluetooth range extender device implementing at least two Bluetooth communication profiles such that the Bluetooth range extender device implements a first role to a first standard Bluetooth communication device and implements a second role to a second standard Bluetooth communication device.

Apparatus and method for extending Bluetooth device range

The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.

Growing community of inventors

San Diego, CA, United States of America

Brian Miller