Battelle Memorial Institute

Brian M Rapko

Dennis W Wester

Matthew J O'Hara

Glenn W Hollenberg

Robert E Schenter

Gregg J Lumetta

Matthew K Edwards

This disclosure concerns a new method for preparing radioisotopes, such as molybdenum-99, by alpha particle irradiation, such as by alpha particle irradiation of zirconium-96. Molybdenum-99 is a precursor to the medically-significant radioisotope technetium-99m. Also disclosed are novel compositions containing one or more of technetium-99m, molybdenum-99 and zirconium species. Systems for producing molybdenum-99 and technetium-99m, including alpha particle generators and irradiation targets, also are described.

Medical radioisotopes and methods for producing the same

Medical isotope generator systems are disclosed according to some aspects. In one aspect, aY generator system comprises a generator column, a concentration column, and a flow control system, through which the generator column and the concentration column are in fluid communication. The flow control system provides a plurality of flow configurations for delivering a milking solution to the generator column, the concentration column, or both, and for delivering an eluent solution to the concentration column in either a forward or a reverse flow direction. The generator column can comprise aSr stock adsorbed on a sorbent. The milking solution preferentially elutesY from the generator column. The concentration column comprises a sorbent that capturesY from the milking solution without altering the milking solution. The eluent solution elutesY from the concentration column.

Medical isotope generator systems

Growing community of inventors

Pasco, WA, United States of America

Brian M Rapko